Alpha-blockers: whakaahuatanga me te whakarōpū

Ngā mihi ki te rangahau pūtaiao i roto i te mara o pharmaceuticals te ako tonu te mahi o te raau taero, te tuku o atu taero tiketike-mahi hou. Ko reira he taero he whānui o ngā mahi e te hunga mahuinga mō tekau tau ngā. Ēnei ngā alpha-blockers.

Nuinga o ngā wā e whakamahia ratou i roto i te maimoatanga raau o takawhita, hoki tukupu pēhanga toto me te he maha o disorders urological, hei tauira, prostatitis ma'i, me te mārire pukupuku prostatic.

History o whakahura

hanga te kitea o te Arepa-blockers i roto i te ahumahi ho'oraa Russian i roto i 1976. Mai i whakaaro ratou drugs whai hua e whakaiti pēhanga toto. Otiia e kore e ratou whakamahi ko nga wa katoa e tika ana no te mea o maha rawa ngā pānga taha. Ko tētahi o te raau taero matamua i roto i tenei rōpū ko "Prazosin". Next, i whakarewahia ai hanga o te tahi atu Arepa-blockers pērā i "Doksasozin" me "Terarozin". Katoa o ratou, me te "Prazosin", whakamahia ki te hamani takawhita, engari rerekē i reira mahi atu auroa.

Engari rerekē hoki i roto i te faito o localization o te wahi me te whakaaro mahi o te Arepa-blockers. Ka kia te aroaro teuteu i raro.

momo

E wehea Adrenergic receptors ki e rua momo:

• Alpha-1 receptors, e kua paetata i runga i te mata o te membrane o te neuron postsynaptic, kawenga hoki te tohu kawea atu mā te whakamahi i tētahi wāhitau atu neurons catecholamine ranei pūtau effector, tae atu etahi pūtau iaia. Ko te putanga o te mahi o enei receptors he vasoconstriction.
• Alpha-2 receptors, e kua kei i runga i te membrane mata o neuron tokanga'i te whakatupuranga presynaptic o norepinephrine i roto i te kapiti synaptic mā te urupare kino, reira whakaiti i te hanga o te noradrenaline, whiwhi i roto i te kapiti synaptic.

Whakatinanatanga receptor pā o Arepa-1 iaia uaua maeneene faaore vasoconstriction whakapataritari catecholamines. I roto i te tahuri alpha-2 receptors kei i runga i te membrane presynaptic o te neuron, e kore e whakapaea, ka i reira he tapatahi o te huarahi urupare, whakapataritari i te tuku o te noradrenaline.

Whiriwhiri 1 (blockers) he te raveraa ra o receptors postsynaptic. Taua medicaments te whakakore mahi receptor tika ki nga pānga o catecholamines tukua i roto i te tohanga, me neurons.

mahi

I pānga tua i runga i te pēhanga toto whakaiti, blockers Arepa (taero tabulahia i raro nei) i te tahi atu mahi. Etokardialnye, pūkoro tinana, extracardiac pānga haumanu. Sci kakama tiketike o tenei rōpū o raau taero i roto i te maimoatanga o huringa i roto i te myocardium, pūnaha coronary, i roto i pa ana pūmua i roto i te repeure.

extracardiac

• Whakaongaonga o nga whatukuhu.
• Purenga o nga korere arahau.
• Whakapai ake o ngā tukanga pūkoro tinana i roto i te pūnaha urogenital i repeure puku Koló.

Alpha-blockers i te pānga pai i runga i te whakaiti tupu puku, me te tohu o te pakeke o te paruparu.

cardiac

• Tuhinga o hypertrophy myocardial.
• Whakahaere manawataki ngakau.

Ki te tūpato hoki o te pānga kino whakamahia i roto i te kore te ngakau, me te angina.

pūkoro

• Whakaititia te mōrea o whakatū papa cholesterol.
• Whakaiti i ngā taumata huka toto (taiāki huka) i roto i te toto.

Ka rite ki whakahuatia i runga ake, maha Arepa-blockers whakamahia i roto i te maimoatanga o mate o te repe repeure i roto i nga tangata.

Ko te taupori toa i runga i te tau o 50 tau, maha mamae i tenei momo o te mate, te tuatahi o e ko te prostatitis me repeure adenoma.

Ēnei mate i te pānga tōraro i runga i āhua o te tangata kia rite ki te katoa. raruraru tamau ki urination, hūhi, paruparu ahu whakamua e te tahi mau fifi no te tangata o tetahi tau. I tua atu, kei te whakaaro te mate i runga ake-whakahuatia ki te whati. e kore e taea maha te mahi kahore pokanga. Hei aukati i te mate whakapeka wāhanga whakamahia taero.

Hoki wawaotanga hauora whakamahia te he-blockers, inhibitors o 5-Arepa-reductase.

Kaupapa inhibitors mahi whakaora

rongo te tupu o te kiko uaua i roto i te repeure te matua hormonal. whakatairanga pūtaiaki reductase 5-Arepa te kōhao i roto i te repeure repe taiaki testosterone panoni ki dihydrotestosterone. Ko te whakamutunga, i roto i te tahuri, herea ki receptor androgen karihi i roto i te repe repeure me whakaihiihi ana te secretion o ngā āhuatanga tipu paracrine, kei te neke ano ratou ki roto ki te repeure. Alpha-blockers, e taea ki te āwhina i roto i tenei āhuatanga inhibitors o 5-Arepa-reductase.

production nui o dihydrotestosterone ai te maha o mate kino pērā i hypertrophy Koló prostatic, te pukupuku mate pukupuku, repeure atu mate urological. I tenei wāhi i roto i te inhibitors whakamahia o inhibitors reductase 5-Arepa rite te akoranga maimoatanga hauora. Ratou pānga haumanu ko te reductase pā, i roto i te tahuri Whakahekea te taumata o DHT, e ai huringa repeure E ruia ana.

Ko te taero tino rongonui i roto i tenei rōpū e "Finasteride" me "Dutasteride". E ratou he pānga haumanu rite, te wā te rongo rerekē, me te talena.

Blockers, Ka taea te hokona inhibitors o 5-Arepa-reductase i te rongoā i runga i whakahaunga.

Otiia i roto i te noa'tu o te tōtika tiketike, taero whakamahia ki te tūpato, me te kore i roto i te wā katoa e tika ana ki te maha nui o mau faaiteraa kino me contraindications.

pānga taha Major ia tango

• I muri i te whakamahi o taero ki te pēhanga toto raro he pea ki hypotension.
• Whakapairuaki, pāhoahoa me whanoke.
• palpitations Heart, hāhā o te manawa.
• mamae uaua, ngoikore.
• Whakarokiroki.
• pupuri wai, edema.
• Mamae i roto i te kopu, me te paru.
• Ihu, hāhā o te manawa, matewai.
• Ētahi atu pinepine i roto i te hawhe wahine o te taupori kitea te whakaongaonga o tōngāmimi ngoikore, urination auau.

Na reira, kia whakamahia blockers alpha-beta ki te tūpato.

Ko tētahi o nga mau hopearaa tino nui ko te hypotension postural, e kia tango te wahi kua i whängainga kotahi. tuatahi puta ona tohu i muri i te hawhe haora ranei te haora i muri i te fariiraa i medicament. E pā ana te nuinga tenei ki "prazosin". Kia kore ai tenei pānga taha, kia te tarukino kia whakahaerea e tipu talena me pai te pō.

I roto i te hononga ki te runga ake ngā pānga taha whakahuatia o blockers Arepa whakaritea i roto i ngā ki Diuretics ki te ārai inu pupuri me painkillers ki atawhai tohu mamae.

Medicaments o tenei rōpū whakaritea te rite te maimoatanga motuhake ranei tukutahi ki ētahi atu rongoā mō te rongoā tini o nga mate.

mate

He maha ngā mate, mo te maimoatanga o e whakamahia Arepa-blockers:

• I roto i te mana o mate hypertensive i roto i te huinga therapy rite te tikanga ki te whakatutuki i te pānga haumanu tere.
• puku mārire i roto i te repeure.
• mellitus Diabetes.
• Pheochromocytoma.
• neoplasm mārere o te repe repeure.

contraindications

I roto i te mea take kore e whakahau Arepa me te beta-blockers?

Ko te contraindications matua mō te fariiraa i taka he:

• pēhanga toto iti;
• maroketanga;
• therapy ki Diuretics;
• ngā malformations cardiac;
• kore ngakau ma'i;
• huangō;
• raruraru manawataki ngakau.

Kaua e whakahau taero o tenei ahua i te hapūtanga me te i roto i te hohipera, ka rite ki nga akoranga taiwhanga pau i runga i tenei kaupapa kua whakahaere.

Alpha-blockers adenoma

E whakamahia drugs Basic o tenei rōpū mo te maimoatanga o te adenomas:

• "Uroksataral".
• "Cardura".
• "Gitrin".
• "Rapaflo."
• "Flomaks".

I roto i te raraunga rongoā ārepa-pūārai. Ko te rārangi haere i runga i.

tikanga o te mahi

Ko te tikanga o te mahi o enei raau taero i roto i te whawhai ki adenoma he kuware, tangohia e ratou te reo o nga uaua o te repeure me te tōngāmimi, ko te kupu te āwhina ki te hiki urination.

Whakahau taua akoranga rongoā maimoatanga ki inenga takitahi, tango kotahi e rua ranei, nga wa i te ra.

Whakahau kāwai rongoā tūroro ki te mate matatau nei i uaua ki urination, a kahore e taero ngoikore i te pānga e hiahiatia ana.

haamata te pānga haumanu matua ki te puta i muri i te wiki o te rongoā. I 14-21 ra i reira ko te tanga manawa nui ki te manawanui.

Ara

Hoki te pānga haumanu tiketike riro i roto i te rua o te Arepa-blockers me inhibitors o 5-Arepa-reductase. Ko te tōtika tiketike o te whakamahi o teuteu taurua whiwhi rite ki te hua o te rangahau haumanu rata.

E kore e tūtohu ana ki te whakakotahi i te rongoā i runga tahitia ana ki taero BADami paruparu ranei. Ka taea e whakarei ake i te blockers pānga haumanu, i te mea houhou. Ko te putanga i taea e te hekenga koi i roto i te pēhanga toto.

kia tētahi atu putanga kino o te whakahaere o te ejaculation blockers Arepa Urologicals i te kōhao o te tōngāmimi. ai te reira i kore nunu'a kovi mo hauora whānui.

A, no te whakamahi i tenei rōpū o medicaments mō te e tohe adenoma tūtohutia ki te whakaiti i te tahi atu raau taero te pēhanga toto. Manakohia hei huānga o te therapy matatini, kia waiho ratou iti whai hua i roto i te maimoatanga o te takawhita.

Hoki tūroro mate i te mate hypertensive ka pā ana ki ngā huringa i roto i te repeure repe alpha-pūārai tūtohu te ki te aroturuki tonu nga taumata pēhanga toto.

Whakatūpatotanga ka tango taero

• Rongoā ki blockers alpha whakamahi anake whakaritea e te tākuta. Te rata e whakatau i te horopeta, te roanga o te fariiraa.
• Maimoatanga ki enei taero kia raro i te mātakitaki o te rata wāhi hauora ranei i roto i nga taiepa.
• A, no te ki te whakakitenga o ngā pānga taha mutu tango i te tarukino, me te kōrero i te tākuta.
• I roto i kore take e kore e huri i te inenga whakarunga takitahi.
• Ētahi atu rongoā tukutahi ki te Arepa-blockers ki whakaae ki te tākuta.
• Kaua e whakamahi i Arepa-blockers hei therapy ohotata mō disorders hypertensive waho te whakaae o te tākuta.
• Kaua e whakaae ki taero pau ranei tarapēke waimaero, kino ki te papa anga pakeke.
• taero Hoko anake raihana pharmacies.
• A, no te fariiraa i te rōpū i runga ake-whakahuatia o ngā rongoā tonu puta noa i te ra, me te i te taotoraa ki te ine i te pēhanga toto.
• Tango rongoā mō te pēhanga toto tiketike i roto i hapūtanga, kia mohio ki te whakaae ki te tākuta.

He mea nui ki te matau e te tuwhena rawa o enei taero e taea arahi ki hopearaa houhou.