Ko te tarukino "Baraklyud": tohutohu mō te whakamahi, whakaahuatanga, hanganga me arotake

"Baraklyud" e pā ana ki taero anti-retroviral, wahi o te rōpū o analogues nucleoside. Whakaritea mo te maimoatanga o ma'i HBV-mate. Ko te whakauru mātātoa o te entecavir tarukino hohoro Kōpeke tukuruatanga viral o kakā.

Me tika kia ako te reira i tuhipoka i mua i te tango i te raau taero. Ka rite ki tohua e te tohutohu mō te whakamahi? "Baraklyud" (Baraclud) - he tarukino tikanga nei ki te tīmata i te backflow o tukanga fibrotic i roto i tūroro ki ate cirrhosis.

te raau taero

E wātea ana i roto i ngā kōwhiringa inenga e rua te tarukino - 0.5 me te 1 mg wae entecavir kaha e ngā rere i roto i te tae tae (ma ranei māwhero, aua).

Te faaineineraa hoki ngā:

• polysorbate;
• stearate konupora;
• monohydrate reihuka;
• Valium;
• povidone;
• colorant Opadry.

pānga pharmacological

Ko te whakauru kaha ko entecavir i te mea he orotahi o te guanosine nucleoside, kua korerotia mahi whiriwhiri ki te kakā B.

Kei te phosphorylated Entecavir ki te triphosphate kaha ki te hawhe-ora o e pā ana ki te 15 haora, i te ihirangi intracellular o nei e pā ana te ki te kukū o ngā pūtau waho entecavir. A, no te kore te tenei kitea whakaeminga appreciable o taonga kaha i roto i te tinana. Medicine "Baraklyud" tohutohu mō te whakamahi i tohu tona pai tiketike, Kōpeke te mahi o polymerase viral, pākaha wā kotahi i runga i ngā āhuatanga e toru:

• ariā o te whenu pai o DNA HBV;
• whakataka tuhinga o te miro tōraro mRNA pregenomic;
• HBV Priming whākōkī.

e kore he Triphosphate he retarders kaha whākōkī DNA pūtau, ara ki te ihirangi nui o kahore pānga i runga i te kōtuitanga DNA punaraungao.

pānga o te tarukino

Ko te taonga tarukino kaha Ko te ahei o te wa poto e whenumi i te pūnaha kūnatu me te tae te mōrahi o ona tirotiro i te 30-90 meneti i muri i tango i te papa.

hua hāngai i roto i te Cmax me kuputohu AUC puta i roto i te te whakamahi muri o 0.1-1 mg o medicament "Baraklyud". Tohutohu mō te whakamahi korero e pā ana ki te whakatutuki i te pauna i roto i te 6-10-th te ra o te horopeta kotahi o te tarukino ia ra. Whakamahi o ngā kai fatty tino fakafaingata'a'ia'i tukanga absorption entecavir, tango waehere Cmax me AUC e 45%, me te 20% te whakaatu i.

Kei te tere whenumi te tarukino i roto i te kikokiko, me te e 13% here ki pūmua wē. e kore te mea e hāngai ana ki substrates, inhibitors whākōkī whāpoapoa o pūnaha P450 ranei te wae tarukino kaha. He mea e taea ki te whakaemi i roto i te tinana, me te putanga i roto i te pūnaha tākihi i filtration glomerular me rere tubular.

Tuhinga

Medicament "Baraklyud" tūtohutia ki te tango i roto i te maimoatanga matatini o te mate ate kakā B:

• Ki te tohu o nāianei o te tukuruatanga viral me hua o te tohu o te mahi o transaminases i te serum, i roto i te aroaro o faaiteraa histological o mumura haere tonu o te ate.
• pāpaka ate Unrecovered.

Nui te tanga o tohu mate ate puta i muri i whakahaere tarukino "Baraklyud". E taunaki ana Papa ako ā-e tūroro ki kakā B, mate ate uaua e te whai ake:

• Kei decompensated;
• huru ate pathological i roto i te taahiraa utu ka tāuta faaiteraa tukuruatanga viral pāngia o ate kakakīrehe ki nui haere AST me te ALT.

contraindications

Ko te tarukino "Baraklyud" kua te contraindications e whai ake nei:

• nui haere susceptibility ki entecavir me ētahi atu matū i roto i te hanganga tarukino;
• reihuka tuku, te kūhuka-galactose malabsorption, hē ngaro i roto i te tinana ranei o te lactase paru ;
• tau iti iho i te 18 tau.

Me te iwi ki te hēnga o ōna whatukuhu ki te tango i te tarukino i runga i whakahaunga me i raro i te tirotiro tamau hauora.

e kore te Reception "Baraklyuda" i roto i hapūtanga tūtohutia i roto i therapy Me ki te mutu whāngai ū.

pānga taha

He pea he momo o disorders o te pūnaha kūnatu i roto i te maimoatanga tarukino "Baraklyud". E mārama fakamatala'i tohutohu mō te whakamahi pānga taha:

• disorders kūnatu;
• korere;
• whakapairuaki me te ruaki;
• dyspepsia.

kia wheako hoki e koe te pāhoahoa, ohoroa ranei te momoe, mate o te hiahia, me mate pāwera.

Hoatu rongoā rite te kaihoko whakaora anake ranei i roto i ngā ki ētahi atu toohunga taea meinga hepatomegaly nui ki steatosis, e kia arahi ki te mate o te manawanui.

I roto i te tūroro ki te āhuatanga nei e pāpaka Tiro decompensated laktatsiadoz kia puta ate,:

• ngoikore uaua whānui;
• manawa tere me te ahua o te mamae o te manawa;
• whakapairuaki;
• whakaiti nui o taimaha tinana;
• mamae i roto i te peritoneum, epigastric.

Ano, Ka taea e te tarukino meinga tauhohe rerekē me te tinana:

• nui haere auau o transaminases ate;
• ponana kiri;
• tauhohenga anaphylactoid.

Ko te tūroro mate hoki te mate ate decompensated, i roto i te tua, taua tauhohe he kaiao whakakitea:

• täkihi (i roto i te wā onge);
• ihirangi bilirubin nui haere i roto i te toto;
• . E tukupu ana o te mōtepe tatau ki te 50 mano / mm ³ iti iho ranei;
• whakaiti o warorua i te toto;
• hua o te ALT;
• neke atu i te hua e toru-puninga i roto i te mahi o te lipase;
• taumata iti o albumin.

Medicament "Baraklyud": Inenga me te whakahaere

kia te tarukino kia tangohia i runga i te puku kau, te wā wa i te kai whakamutunga i mua ki te dosing kia neke atu i te rua nga haora.

A, no te utua ate kino fariiraa tūtohu "Baraklyuda" 0.5 mg ia. I roto i te tāutu ātete ki lamivudine inenga kia rererua.

Tūroro ki pāpaka ate unrepaired whakaritea rōpū rā, o 1 mg. Hoki te kaumātua me te tūroro ki te iti hoki tākihi, kia whakaritea te horopeta i runga i te taumata o te CK (creatinine kukū) i roto i te toto rānei.

tuwhena rawa

e kore he nui Information i runga i ngā take o te tuwhena rawa tarukino.

Volunteers, i hauora i whakamatauria, riro he inenga rā o te 20 mg mō te rua wiki i hoatu e ratou i te horopeta kotahi teitei - 40 mg tarukino "Baraklyud". kī Tohutohu mō te Whakamahi i kitea pānga kino.

maimoatanga posindromnoe Manakohia raro i te mātakitaki o faaiteraa haumanu.

Ngā pāhekoheko ki ētahi atu taero

Nā ki te meka i excreted te entecavir wae kaha te matua i roto i te pūnaha tākihi, therapy matatini i roto i ngā ki ētahi atu taero e whakarato pānga hāngai ranei i runga i tākihi mahi me te pā secretion tubular, kia hua i roto i te hua i roto i te tinana o te entecavir me nga matū kaha o raau taero.

Ngā pāhekoheko "Baraklyuda" ki adenovirom, tenofovir, kihai i tuhia lamivudine.

mehua whakatūpato

Whakaae o nga tūroro tarukino ātete ki te lamivudine arata'i ki te mōrea o te whakawhanake i resistance.

Ano, i reira he taunakitanga o te takanga o exacerbations o kakā B i muri korenga atu o te tarukino "Baraklyud". Tohutohu mō te whakamahi whakaahua ana te tanga o exacerbations kahore therapy atu.

Ara

Reception "Baraklyuda" i roto i te anga o te monotherapy me maimoatanga ngā ki ētahi atu āpiha toohunga, taea meinga acidosis lactic, hepatomegaly ki steatosis. I roto i tenei take, i reira he he tūpono o te mate.

I mōrea tūroro ngā te kāwai e whai ake nei:

• mate ana i te hepatomegaly;
• ki te kia tukinotia ki te whakamahi o analogues nucleoside;
• he taumaha;
• tūroro wahine.

Tohutohu mō te whakamahi o te tarukino "Baraklyud" tapao ra te taea o te hanganga o taumahatanga viral ātete. e kore te Active tarukino whakauru entecavir tūtohutia mo te maimoatanga o te tangata huaketo ārai no o tona kakama i roto i tenei aronga, kua kore ano ako i roto i te ki tonu i.

I roto i te maimoatanga o te tūroro ki māuiuitanga o te pūnaha tākihi, he tika ki te whakatika i te horopeta.

E kore e te haumaru me te whai huatanga o te whakamahi i "Baraklyuda" mo te maimoatanga o te tūroro i muri i ate transplantation mohiotia me rapu utu mehua tiaki tautukunga motuhake.

tikanga Rokiroki me te utu

kia kawea Storage me transportation o ngä pire i roto i te whānuitanga pāmahana 15-25 ° C. he pai hoki te whakamahi mō te rua tau i te rā o te hanga te faaineineraa.

ngā te raau i roto i te rōpū motuhake o ngā rongoā faufaa, a no te mea whakaturia etahi ngā kāwai o tangata tuku noa o te tarukino "Baraklyud". Tohutohu mō te whakamahi hopu tenei meka.

tikanga utu i roto i pharmacies Moscow tīmata i te 12 mano. moni.

Tirohanga o tūroro

tohu te reira i te miramira tiketike o te tarukino "Baraklyud" ā-ako. Utu, arotake o nei whakakitea e ko te reira manapori i rite ki analogues o te raau taero, rerekē i waenganui i 12-17 mano ia mōkihi, i roto i nei 30 pire. hanga te tarukino he tino hira me i roto i te tono i roto i te tūroro mo te maimoatanga o te kakā B. tenei

I roto i te urupare tōraro tuku te nuinga proitvopokazaniya me taha pānga o te raau taero, pērā i ohoroa, me whakapairuaki.