Syndrome Carcinoid: tohumate, tātaritanga, me te maimoatanga

whakaatu tatauranga Medical e kua te maha o te mate pukupuku, kua maranga tamau. putanga Fatal i tuhia piki katoa tau. Tenei meka Ko te atu katoa, whakapouri ai rata ki te whakahaere i te mahi ārai i roto i te taupori i roto i te tikanga ki te pupuri i te tupu whwhi pukuriri iti moka.

syndrome Carcinoid: he aha te mea te reira?

Carcinoid - Ko te puku tino noa o te pūtau o te pūnaha neuroendocrine tenei. pea ēnei pūtau i roto i tetahi okana me te kopa. Ratou mahi matua - ki te whakawhanake i pūmua kaha tino. Mō waru tekau ōrau o carcinoids katoa e kei roto i te wahi gastrointestinal, i roto i te wahi tuarua ko te pūkahukahu. He nui atu uaua,, kua kitea ōrau e rima anake o te wā pukupuku i roto i te tahi atu whēkau me te kopa.

e kore e taea te wehea syndrome Carcinoid me puku carcinoid i ia atu, rite te syndrome - he huinga o ngā tohu e puta i roto i te papamuri o te tupu, me te mahi o te repara. I muri i te katoa, tauhohe te tinana ki te whiwhi ki te hormones toto huna ana e te puku. kia "wahangu" carcinoids whēkau, e kore e ie whakaatu ano tae noa ki taua wa ra ano i reira he metastases, me te kore e te mate e haere ki te atamira kāpeka.

take

Kairangahau tonu e kore e nui ngā mōhiohio ki te matau he aha te whakawhanake syndrome carcinoid me puku carcinoid. Ka taea e Scientists hanga whakapae e pā ana ki te mate etiology, engari whakaae katoa i runga i te meka e te pūnaha ārai i etahi wāhi mutu ki te ite i ngā pūtau mutated pūnaha With (he acronym o nga reta tuatahi o te kupu "Amine," "mua", "whakawhenumi", "decarboxylation" ).

He pūtau pukupuku kotahi i roto i te tikanga ki te roto o reira whakawhanakehia te tupu hou oti e ka whakaputa hormones me te whakarerekē ki te hāngai o koutou hiahia nga tukanga matüora katoa i roto i te tinana tangata.

pathogenesis

Pehea e taea te whakawhanake syndrome carcinoid? He aha te mea te reira, ka pehea ki te ārai i te reira? Hoatu e ngā pūtau neuroendocrine kei puta noa te tinana, me mau faaiteraa haumanu o te puku tata kore e mutu te tukanga, e kore e taea e tākuta.

I te hoê taime i roto i te pūtau, ko "kore" DNA ora ake nei te rānei hē tonu ki te mahi ki te kongakonga pakaru. arata'i tenei ki te rangirua o te mahi a te pūtau me tona wehenga whakakeke. Ki te he ora te tinana, ka tauhohe te pūnaha ārai mate ki te irakētanga me ki te pehea o te tūemi tūpato. Ki te kore e tenei pa, na ka tini te pūtau, ka hanga milioni o kape, me te tīmata ki te horapa i roto i nga tāoke tinana me hormones.

maha kore tākuta ki te tautuhi i te wāhi o te puku, ahakoa syndrome carcinoid symptomatic.

Mate pukupuku o te pūkahukahu

ōrau tekau o nga take i roto i te pūnaha romahā anake kia whakawhanake huamo me, no reira, syndrome carcinoid. Signs i roto i te pūkahukahu, ka kia kore motuhake-, a kahore te tahi mau taime i te katoa. Ko tenei e tika ana ki te rahi āhua iti o te pukupuku, me te ngaro o te metastasis. Tūroro rapu tokoni mai te mate matatau me te, rite ki te tikanga, e kore e he matepukupuku rānei, me te tuatahi ki te kaihaumanu. taea i hua kore ia ki te hamani bronchiolitis, huangō kore romahā ranei, tae noa ki te aroaro whakapae o tukanga mate pukupuku.

Tohu i roto i tenei take, ko te mohiotia:

• palpitations, palpitations;
• dyspepsia;
• ongo'i te wera me te wiwi o te toto ki te hawhe o runga o te tinana;
• mare, hāhā o te manawa;
• bronchospasm.

Ki tenei huinga o disorders taea whakauaua te whakapae carcinoid. No kēkeno, uruhi mate taimaha, whakaiti o te mate, rohirohi, me ētahi atu tohu āhuatanga o te tukanga mate pukupuku.

puku whēkau iti

I roto i te kōpiro iti paku atu pinepine atu i roto i te pukapuka, tuhia te puku kei te me ona tahi syndrome carcinoid. He tino mutu tohu o reira. E mea pinepine i reira e anake kore-motuhake mamae puku. Ko e tika ana ki te rahi iti o te puku tenei. I te tahi taime e kore e taea ki te kitea e noa i runga i ngā mahi. Kei te maha Mātauranga kitea e tupono noa i roto i te whakamātautau radiological.

Anake e pā ana ki tekau ōrau o te pukupuku katoa o te whēkau iti o te etiology o te take o te syndrome carcinoid. Hoki te tākuta, tenei te tikanga e meinga te tukanga kua mārere ka horapa ki te ate. Ka taea e ēnei pukupuku meinga obturation o nga lumen o te whēkau, me te rite ki te hua, arai intestinal. Ko te manawanui mai ki te hōhipera ki te mamae-rite, whakapairuaki, ruaki me disorders o te heamana. A ka mohio te take o tenei huru anake i runga i te tepu whakahaere.

kia meinga arai i te rahi puku hāngai, me te torsion whēkau tika ki ari o kakakīrehe me te mumura o te membrane mucous. I te tahi taime whakakorikoria nga tohu rere toto ki te rohe whēkau, e tika ana ki te necrosis me peritonitis. Ko te ora-riri Tetahi o enei tikanga, me te kia arahi ki te mate o te manawanui.

He puku o te tāpiritanga

Te pukupuku o te tāpiritanga - he takanga onge i roto ano. I roto ia ratou noho carcinoids te wahi tuatahi e whakahonoretia ana, engari meinga whakauaua syndrome carcinoid. Tohu o ratou tino mutu. Ka rite ki te tikanga, ko reira te kitenga o Pathologists i muri i appendectomy. Huamo i roto i te rahi, ko te iti iho i te kotahi henimita me whakatoatoa rawa "ata". Ko e i muri i te tango o te puku o te tāpiritanga puta i roto i etahi atu wahi, iti tūponotanga.

Otiia ki te kitea te puku i roto i rua henimita i te rahi, me te ake, kia waiho koutou tūpato o metastasis i roto i nga taikiri rohe me te whakahörapatanga o ngā pūtau puku i roto i te tahi atu whēkau. appendectomy noa i roto i te take i taua e kore e taea e akakoromaki i nga whakaaturanga katoa, a ka whai ki te kukume oncologists ki te whakahaere i te maimoatanga whānui.

pukupuku carcinoid Rectal

Ko tētahi atu localization, i roto i nei kore tata whakahuatia syndrome carcinoid. No tohu o te puku, me te tūpono kitea i roto i ngā tukanga tātaritanga pērā i colonoscopy sigmoidoscopy ranei.

Ko te tūponotanga o te repara (repara), me te ahua o metastases tawhiti tei runga i te rahi o te puku. Ki te he reira nui atu i te diameter o rua henimita, te mōrea o pōauautanga ko e pā ana ki e waru tekau ōrau. Ki te kore e te puku mau ake ki te kotahi henemita te whānui, e taea e koe mohio ki te iwa tekau-waru ōrau, kahore he metastasis.

Na reira, he rerekē te huarahi ki te maimoatanga i roto i enei take e rua. nekehia atu te puku iti te resection te tikanga economical o te kopirua, me te mea i reira he tohu o te repara, e rapu utu i te reira tango o te kopirua katoa, me te hahau.

carcinoid pekitīlia

E toru ngā momo carcinoid pukupuku o te puku, meinga syndrome carcinoid. Ko te āhuatanga o te momo tuatahi o te pukupuku:

• āhuatanga iti (ki runga, ki te 1 cm);
• akoranga Koló.

horapa pea o te puku uaua ka hopu te tukanga i te puku katoa. E pā ana ratou ki te anemia pertsinoznoy ranei gastritis ma'i i roto i te manawanui. Maimoatanga o taua pukupuku, ko te ki te farii i inhibition somatostatin o hanga o gastrin gastrectomy ranei.

tupu āta te momo tuarua o te puku, uaua riro matepukupuku. He parare i roto i te tūroro ki te mate ira ratou pērā i neoplasia endocrine maha. Kaua e miharo noa te kopu, ko te repe pineal, thyroid repe, repe taiaki.

Ko te momo tuatoru o te puku - he puku nui tipu i roto i te puku hauora. He mārere ratou, tomo hohonu ki te taiepa tinana, me te whakarato i metastases maha. Kia meinga perforation me te toto.

Te pukupuku o te kopirua

Ko te piro nui - ko te wahi i reira pāngia te tino pinepine syndrome carcinoid me puku carcinoid. mucosa Photo i roto i te whakamātautau o te wāhanga whēkau whakaatu te aroaro o nui (e rima henimita atu ranei) pukupuku. metastasize ratou ki taikiri rohe , me te he mārere tata tonu.

E tohutohu Oncologists i roto i ngā take pērā ki te pokanga tuwhena ki adjuvant me hahau neoadjuvant ki te whakatutuki i te pānga pai. Ko ora waitohunga mo enei tūroro he tonu kino.

Syndrome Carcinoid: tohu, whakaahua

Ko te mau faaiteraa o te syndrome carcinoid tei runga i te aha matū e tangohia puku. Ka taea e hei serotonin, bradykinin, histamine ranei chromogranin A. tenei nga tohu tino angamaheni o te mate e:

• Whero o te mata, me te tinana o runga. puta te reira i roto i tata tūroro katoa. Tahi e te hua rohe i roto i te pāmahana. Patua tupu noa, e taea te rongo ratou i te waipiro, te ahotea mahi ranei. I roto i tenei take, i reira he tachycardia, makaka pēhanga.
• Inoino o te heamana. ¾ reira i roto i te tūroro. Tikanga, puta tenei e tika ana ki te ritenga o te membrane mucous o te wahi kūnatu, disorders o whēkau tukuna ai.
• Tauwhatinga o te ngakau e tūturu i roto i te hawhe o te tūroro. whakatairanga syndrome Carcinoid hanganga o te ngakau piha stenosis me ai kore cardiac.
• Wheezing i roto i te pūkahukahu e tika ana ki te spasm o te bronchi.
• e pā ana mamae puku te ki te putanga o metastases i te ate, te tutukitanga intestinal ranei puku whakaekenga ki ētahi atu whēkau.

raruraru Carcinoid - he tu'unga āhuatanga e te e te topata koi i roto i te pēhanga i roto i te pokanga. Na reira, whakahaere tūroro somatostatin ki whawhe rite.

tātaringa

He reira taea ki te kitea syndrome carcinoid? Tohu, whakaahua, e kore e maimoatanga rerekē o tohu hoatu he pikitia haumanu mārama, kahore hua kitea. Nuinga o ngā wā i te puku - he kōpeka kitea he tākuta radiologist ranei. I roto i te tikanga ki te whakaū i te aroaro o te pukupuku, he mea e tika ana ki te mahi i te unuhanga o te wahi i pangia, a titiro te kiko.

Ka taea e tonu e koe te whakamahi i te whakamātautau ki te kitea taumata teitei o hormones, engari kia kia tohu o etahi mate enei raraunga, me kua ki te feruri i roto i o ratou kua ia ki te mahi i te tākuta. Ko te whakamātautau motuhake tino ko te maha o te waikawa 5-hydroxyindoleacetic. Ki te nui haere tona taumata te, te tūponotanga o te carcinoid - tata 90%.

hahau

E hanga reira tikanga ki te hamani syndrome hahau-carcinoid? Tohu, mucosa whakaahua i EGD unuhanga taikiri rohe me huringa hormonal taea hoatu te tākuta he whakaaro o nga pōauautanga e kua meinga i roto i te manawanui te aroaro o te puku. Ki te he kino mo te manawanui te matapae noa, ki te te tango o te puku, nga tohunga tohutohu ki te huihui ki te hahau.

Nuinga o ngā wā, te whakamahi i tākuta māngai cytotoxic ki te tautāwhi i te tupu me te whanaketanga o te pukupuku. Otiia no te mea o te tau nui o ngā pānga taha o tenei tikanga tūtohutia te anake i roto i te take o te ohotata. Haunga tona whai huatanga - 40 anake%.

maimoatanga symptomatic

He mana'o fiemālie e kua kitea i runga i te whakamārama o pathologies pērā i syndrome carcinoid, puku carcinoid. Tohu ahu ki te kia e pā ana tata ki te momo o te taiaki e tuku puku. Ki te he serotonin tenei, te manawanui ko pōuritanga tikanga. Ki te te matua "te kaipahua," he histamine, ka haere mai ki te mua blockers receptors histamine i therapy.

analogues waihanga o somatostatin kua kitea, whakaiti tohu e tata 90%. tautāwhi ratou te hanga o te maha hormones e he kawenga mō o ratou wahi u i roto i te maimoatanga o tenei mate.

therapy operative

He taahiraa nui i roto i te maimoatanga, ko ki te tango i te puku i te tinana, a rapu metastases resected, ate uaua ligation.

I runga i te rōrahi o te pokanga pānga te wāhi me te rahi o nga pukupuku, te aroaro ngaro ranei o metastases. Nuinga o ngā wā, tango tākuta te wahi turoro o te tinana, me pōkai o taikiri rohe. Ka rite ki te tikanga, te reira nui ki te whakaora iwi i carcinoid ake ake. I roto i te wā matatau, ka kore e taea maimoatanga curative, karangatia te manawanui e ki te whakapau embolization o te iatuku ate ki te tango i te tohu o te mate.

outlook

He aha ki te titau tūroro pāngia ki te syndrome carcinoid me puku carcinoid? Makere, palpitations me pāngia o breathlessness, he pea ki te noho ki a ratou tae noa ki te mutunga o te ora, engari ka riro iti korerotia i muri i maimoatanga.

Medicine, i reira he take te wahi neke atu i te kotahi tekau nga tau i ora nga tūroro i muri i te pokanga, me therapy symptomatic. Ko ratou whanganga ora toharite ko e pā ana ki 5-10 tau. Ko te kino rawa waitohunga he puku kei roto i te pukapuka, me te pai - i roto i te tāpiritanga.