"Endoxane": tohutohu mō te whakamahi, ritenga tūturu, te kaiwhakanao

Drug "endoxane" e pā ana ki te rōpū o māngai anti-puku. Tei runga i te puka o te tuku e taea te whakahaere i te reira-waha parenterally ranei. He aha te momo o te tarukino whakarite me te i roto i te mea inenga, solves tākuta anake i runga i te kaupapa o te huru tūturu o huru o te manawanui.

Te hanganga me te āhuatanga o te tarukino

Ko te whakauru matua kaha o te tarukino "endoxane" tohutohu mō te whakamahi e pā ana ki cyclophosphamide. Kotahi papa kei 50 mg o reira. E pā ana te rongoā ki te rōpū o drugs antitumor me ko he papa biconcave ki te kōpaki ma, me te matua o te hue kotahi. Ka rite ki atu wāhanga hua ho'oraa hohe kei konupūmā pākawa waro me te hauwai Phosphate, te konutai karamellozu, nonireka, gelatin, reihuka, te witi māngaro, macrogol, stearate konupora, polysorbate, sucrose, talc, silica me te Titanium.

He aha te mea te Pūtaiao o te tarukino?

Ko te matua taonga tarukino kaha, ara cyclophosphamide, alkylating me he pānga cytostatic. Na roto tona āhua, he reira tata ki te pua nani hau, hauota he tona orotahi.

Ko te tikanga o te mahi o te cyclophosphamide i runga i te hanganga o crosslinks i waenganui i ngā rāpoi ngota DNA me te RNA me tinana kōtuitanga pūmua pehi.

Ko te pharmacokinetics o te tarukino

Ko te matua whakauru kaha "endoxane" kua tata oti tohu o absorbability i te wahi gastrointestinal te tarukino. Ko tōna kukū i roto i te toto i muri i whakahaere-waha, me te rō-uaua Ko te taua. puta pākia Cyclophosphamide matua i roto i te ate, i reira i raro i te mana o te microsomal oxidase tikanga ko te hanganga o metabolites alkylating kaha. E tahuri etahi o ratou ki puka hohekore, kua oho tetahi rōpū ki ngā pūtau, te wahi puta te mahi enzymatic o phosphatases ki matū ki ngā āhuatanga cytotoxic.

He hokiate te tohu o here o te ahua taketake o te tarukino me te pūmua toto, me te he 12-14%. Heoi, ōrite kua te taua tohu o metabolites 60%.

cyclophosphamide whakaputaina e excretion tākihi te nuinga i roto i te puka o metabolites. Tata excreted 5-25% o te tarukino e i roto i tona puka taketake i roto i te mimi me te ate.

Tawhā T1 / 2 i roto i te raau taero ōrite 7 haora mō ngā pakeke, me te 4 haora mō ngā tamariki.

I roto i te aha horopeta ki te tango i te rongoa?

Drug "endoxane" i roto i te puka papa tangohia waha te aroaro o te kai ranei te hawhe haora i muri i te kai, i muri i te 2 haora.

Nā ki te meka i ngā te hua ho'oraa i roto i te maha nui o regimens chemotherapeutic, te aratau kōwhiringa o whakahaere me te inenga rata whakaaro takitahi.

"Endoxan" - papa - aratohu taunaki ana te inenga 1-3 mg / taimaha tinana kg ia ra, e ai kia i 50 ki te 200 mg cyclophosphamide mō te 24 haora. Ko te roanga o te maimoatanga he 2-3 wiki.

Ki te tangohia te tarukino te tahi ki te tahi atu raau taero e whai āhuatanga anti-puku, te inenga o nga āhuatanga katoa o te therapy te whakamamaetia ako.

Ka taea e reira kia he tuwhena rawa?

E kore te te aroaro o te raau motuhake i roto i te faaineineraa "endoxane 'tohutohu mō te whakamahi whakapumautia. I roto i te take o rawa te horopeta hiahiatia tūtohutia hoki therapy tiaki rite maimoatanga tika o ngā mate hopuhopu, tohu withdrawal cardiotoxicity me myelosuppression whakakorenga.

Ka rite ki te rongoā ngā te ki atu taero?

Ki te tango te manawanui nga tikanga whakapataritari microsomal hāora i roto i te ate, na te maimoatanga ngā ki te tarukino "endoxan" ako tohu nui ake te ariā o metabolites ki mahi alkylating, heke hawhe-ora o cyclophosphamide me te whakapiki ake i tona pai.

Tenei raau inhibits mahi cholinesterase me te rehukeka ara pūkoro, te whakanui ake i tona tāoke, a whakanuia ana te tōtika o te suxamethonium.

Ki te "endoxane" whakamahia i roto i te taha ki "Allopurinol" e reira te nui haere ona pānga kino i runga i te hinu wheua wheua.

I roto i te take o te maimoatanga tukutahi ki cyclophosphamide, colchicine, probenecid, te tikanga papaki sulfinpyrazone tākuta horopeta taero anti-kauti. e pā ana tēnei i te nui haere mōrea o te nephropathy i roto i te tono tahi "endoxane" ki taero uricosuric.

te whakaiti Cyclophosphamide āhuatanga ariā i roto i te ate, he kawenga mō te toto upoo- me mōtepe production, Heoi, i te maimoatanga ki anticoagulants heke mahi o te muri.

Tūroro tango i te tarukino "endoxan" ā-ako taunaki ana te kai hāunga hīmoemoe wai, mai kei reira wāhanga e ofati i te tōtika whakahohenga me te whakauru matua kaha o te medicament.

A, no te tahi-whakahaere ki te cyclophosphamide "Doxorubicin" ranei "daunorubicin" te rahi roa'tu, pānga cardiotoxic o enei taero.

I ngā ki ētahi atu immunosuppressants, pērā i "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" arata'i ki te hua i roto i te takanga o te mate tuarua, me te momo puku.

I roto i te take o te whakamahi tahi "endoxane" me "Lovastina" i roto i te tūroro ki te transplantation ngakau kia te mōrea o te rhabdomyolysis me te täkihi i roto i te puka whakapeka.

Ki te maimoatanga ki cyclophosphamide ngā ki mielosupressantami ranei ki radiation therapy, he reira taea ki te riro ugneeniya mahi wheua wheua.

Tukutahi fariiraa "endoxan" ki tiketike-horopeta cytarabine i roto i whawhe faaineineraa ki wheua wheua transplantation whakanuia ana te pā o cardiomyopathy mate.

Nahea tenei tarukino i runga i te mahi whakaputa uri?

Drug "endoxane" mua manawanui whakamatau reira, ka taea e whakapataritari sterility i roto i te tūroro o e rua tane, e ai kia tina heke.

I roto i te nuinga o te wā, puta nga wahine amenorrhea, engari te nuinga o ora auautanga paheketanga i roto i te marama torutoru i muri i maimoatanga ki cyclophosphamide. Ki te kawea therapy i roto i roto i ngā kōtiro prepubertal, i kitea ine i roto i te whanaketanga o faaiteraa fakasekisualé tuarua. i noa paheke, i ngaro hua.

I roto i te maimoatanga o tane tarukino "endoxane" ako tohu e korerotia i roto i ētahi wā i azoospermia oligospermia ranei. Ko e tika ana ki te nui haere te hanga o gonadotropins i te tere o te tuku testosterone tenei. e kore te taumata libido me te mananga i roto i nga tangata iti. Ki te maimoatanga ki cyclophosphamide whakaputaina i roto i te mau tamaroa prepubertal, kua puta nga faaiteraa fakasekisualé tuarua obazovanie noa. Heoi, take o azoospermia, oligospermia me te whakapai ake o gonadotropins kua tuhia. Ka taea hoki te puta te reira i atrophy testicular. E tano ia tapao e he reversible te azoospermia, ahakoa e taea te ora o nga mahi puta i roto i te tau torutoru i muri i te mutunga o te maimoatanga.

He aha e nga pānga taha o te tarukino?

Tango rongoā "tohutohu endoxane 'hoki whakapumautia whakamahi te, kia meinga ai te tahi mau disorders o te pūnaha hemopoietic:

• Leukopenia, neutropenia - pinepine.
• He anemia me thrombocytopenia Iti noa.

I muri 1-2 wiki i te timatanga o te maimoatanga, tohu te manawanui te whakaiti mōrahi o leukocytes me platelets i roto i te toto. E whakahokia ēnei tawhā ki noa i roto i 7-10 ra o te mutunga o te therapy.

I roto i te maimoatanga ki cyclophosphamide taea meinga tauhohe taha o te wahi gastrointestinal:

• Whakapairuaki me te ruaki.
• Anorekisya.
• Stomatitis.
• Mamae i roto i te rohe puku.
• kōtītiti kumete.
• Jaundice.
• colitis hemorrhagic.

Uaua puta pōrearea ate e pā ana ki nui ake mahi o whākōkī me ngā taumata bilirubin ara. Tino he rōpū nui o tūroro e whai anemia aplastic me riro teitei-horopeta "endoxane" ranei te whakakotahi i te reira ki te busulfan, e ai ta endoflebit uaua ate. Ka taea e tēnei āhuatanga puta 1-3 wiki i muri i te wheua wheua transplantation me te whakakitea i roto i te hua koi i roto i te papatipu tinana, ascites, hepatomegaly me hyperbilirubinemia, ate encephalopathy.

I mua i taea te tarukino meinga tauhohe houhou ki te kiri:

• alopecia Reversible.
• Ponana.
• Ko te ähua o te kiri, me te whao.

taea hoki te te rongo te reira e te takahi o te pūnaha mimi i roto i te maimoatanga o te tarukino "endoxane". Tohutohu, ki arotake o tākuta me tūroro tohu āhua rerekē:

• Cystitis honoa ki te kakakīrehe tōngāmimi (ranei kahore reira).
• urethritis hemorrhagic.
• tubule ari Necrotic mate noa.

I roto i te mimi, kia kia kitea te manawanui i te epithelium o te tōngāmimi mimi. Ki te te puka cystitis o hemorrhagic taimaha, mutu tango i te raau taero. Ko te ārai pai o tenei huru ko te rongoā "Mesna". Ki te nui haere "endoxan" horopeta, taea whakawhanake pōrearea tākihi rite nephropathy me giperurekemii.

Ki te mea he tohu nui o te immunosuppression te manawanui, na kia ite i te maimoatanga o te cyclophosphamide mate nui.

Hoki e taea te whakawhanake i te pānga taha e whai ake:

• Cardiotoxicity (pota teitei), tohu nui o te kore ngakau.
• kakakīrehe pūkahukahu, āhua interstitial.
• Tauwhatinga o te spermatogenesis me oogenesis, reversible me sterility tina heke.
• Ko te whanaketanga o te tuarua neoplasms mārere pērā i te mate pukupuku o te tōngāmimi, mieloproliferatsiya me lymphoproliferation.
• Pāwera rite hikaka, minamina, urticaria, i ētahi wā i roto i te puka o te tauhohenga anaphylactic.
• whakaora marutanga rawakore.
• Makere kanohi, sweating, ānini.

Ko te oraraa o ngā pānga taha nui i tango i te raau taero e tonu whakaara ake te pātai e pā ana ki te painga ka taea ki te tūponotanga ka taea hoki te manawanui takitahi.

E mate whakahau tenei tarukino?

Papa "endoxan" kia whakaritea ki te manawanui, ki te he te reira i te mate e whai ake nei:

• mate o Hodgkin.
• myeloma maha.
• mate pukupuku uma.
• lymphoma Lymphoblastic i roto i te puka whakapeka ma'i ranei.
• momo lymphoma Non-Hodgkin o.
• Retinoblastoma.
• Neuroblastoma.
• pūāhua gribkovidnogo Mycosis.

tohu te reira i te tali o te tono i roto i te therapy anticancer matatini piri ki te tarukino "endoxane" ako. E taunaki ana te kaihanga e ngā reira i roto i te maimoatanga o te pukupuku i te waha, me te mate pukupuku tōngāmimi, mate pukupuku pūkahukahu, me te matepukupuku repeure, sarcomas me reticulosarcoma, mate Ewing ko Wilms.

Ka taea te whakamahi i te hāngai cyclophosphamide-tarukino rite immunosuppressant mate whakamua autoimmune rite, psoriatic me te kaikōiwi, anemia haemolytic, collagen mate, syndrome nephrotic, me te ki te karo i uhi makanga.

A, no te contraindicated te tarukino te?

Ko te medicament "endoxan" kua he contraindications taimaha, tae atu:

• Pregnancy me te hohipera.
• Cystitis.
• Mate i roto i te puka hohe.
• Tūkinotanga o wheua wheua mahi i korerotia puka.
• Ko te aroaro o te hypersensitivity ki te matū taketake, me te atu tarukino.
• pupuri mimi.

rata tiaki Special whakahau te raau taero i roto i mate o te ngakau, whatukuhu, me te ate, kino, kauti, adrenalectomy, te aroaro o ngā tukanga kookuhutanga i roto i te hinu wheua wheua, nefrourolitiaze.

arata'iraa Motuhake i roto i te maimoatanga o

I roto i ingestion "endoxan" raro ki te toto mana obligatory (neutrophils me tatau mōtepe) me te mimi (te aroaro o ngā pūtau toto whero) o te manawanui.

e tūtohu ana ki te mutu maimoatanga tikanga "endoxane" i roto i ētahi wā. tūtohu Tohutohu i runga i te whakamahi o pire ki te rave i te reira i raro i te tikanga e whai ake nei:

• tohu faaiteraa cystitis.
• E tukupu te kukū o leukocytes me platelets ki te uara tino.
• Takanga o te mate (he taea horopeta ako).

Ki te whakamahia "endoxane" Kei roto i pota tiketike, whakaritea te manawanui te rongoā, "Meena" mo te ārai o te momo hemorrhagic cystitis.

I roto i te maimoatanga ki tenei raau kia pehi i inu waipiro me te whakamahi i ngā tikanga pono o te ārai.

Ki te whakaritea te manawanui ko "endoxan" mo 10 ra i muri i te pokanga ki rehunga whānui, mōhio te anesthesiologist kei e pā ana ki tenei.

I muri adrenalectomy i mahi he horopeta whakatikatikanga "endoxane" me ētahi atu taero corticosteroids.

analogues tarukino

Ki te mea i reira he contraindications nui me tūponotanga, ka whakaekea ki te hoatu ki runga tango i te rongoā "endoxane" ako. Ka taea te whakaritea e te tākuta hei kē e tika ana Analogs. I roto ia ratou:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "-Lens Cyclophosphamide".
• "Endoxane - Astana".

Tenei mōhiohio Ko te putanga māmā o te tohutohu ki te tarukino "endoxane". hanga te whakaaro o tenei raau e anake e te rata haere.