Ko te tarukino "Ursodez" - tohutohu mō te whakamahi. Papa "Ursodez": analogs me arotake

Drug "Ursodez" - tarukino hepatoprotective. He medicament choleretic, hypolipidemic, mahi holeliticheskoe, roaa hypocholesterolemic me te pānga immunomodulating hokiate. taonga hohe - waikawa ursodeoxycholic. Te raau e kore puka inenga "pire". "Ursodez" hua i roto i te puka o capsules.

tikanga mahi

Ko te taonga tarukino kaha kua te kaha ki te whakauru ki te membrane o hepatocytes, aueue tona hanganga. Ka rite ki te hua, e tiakina nga pūtau i ngā āhuatanga rarua, te mahi o tai waikawa ate. Ko te pānga haumanu o te tarukino te whakakitenga mai te kupu tukupu te pānga cytotoxic. Ki te whakamārama o te cholestasis whakahohetia Ca2 + ti'aturi protease exocytosis alpha-whakaongaonga. Tikanga "Ursodez" (tono Kaiwhakamahi tohu reira) nui te whakaiti i te waikawa ate paitini (deoxycholic, lithocholic, chenodeoxycholic me ētahi atu) i nohanga teitei i roto i te tūroro ki pathologies ate i roto i te akoranga ma'i.

A, no te fariiraa i rongoā tohua hekenga i roto i cholesterol kōtuitanga me secretion, inhibition o tona absorption i te whēkau. Nā ki tenei, heke reira te waiwai o te ate ki tenei pūhui. Ko te faaineineraa e te kaha ki te whakataetae whakaiti absorbability o waikawa lipophilic i te whēkau, te whakanui ake i to ratou rerekē oneone tohanga enterohepatic hautanga. Rongoā whakaongaonga te excretion o waikawa paitini, nui haere irava.

Kei te hāngai hoki te tikanga o te mahi o te tarukino i runga tātari waikawa ate nonpolar. No te mea o tenei paitini micelles whakauru. Tikanga intensifies i roto i te pūnaha biliary, te memehatanga o te cholesterol, e faaau hanga me te secretion o ate. whakaiti hoki te tarukino tona lithogenicity, faarahi te kukū o te waikawa, ko te kupu whakapataritari he hua i roto i te mahi o te secretion pancreatic me pekitīlia.

A, no te fariiraa i te capsules i whakakorenga oti te kanohi ranei o kohatu. Na roto i te whakaiti i te ate cholesterol waiwai whakarei roopu o kohatu. whakaaturia mahi Immunomodulatory te tika ki te mana i runga i te tauhohenga tēnā i te ate. te whakaiti i te tarukino te faaiteraa o te maha o antigens histocompatibility. Ko te medicament he pānga i runga i te taumata o T-lymphocytes, heke te maha o eosinophils.

tikanga Pharmacokinetics

Absorption o te tarukino "Ursodez" (ako ā-tohu tenei) i roto i te kōpiro iti whakamana e te tukanga o te tūringiringi hāngū. Tangohia ki pā ana ki 90% o te wāhanga hohe. I roto i te ileum horomia te taonga e waka kaha. Ko te ihirangi teitei o te wae kaha āhua kotahi haora tae. Te pūhui he ōrau nui o te pūmua here - 99%. waikawa Ursodeoxycholic taea ki te tomo i te ewe ko.

Ko te miramira whakaora o te raau taero tei runga i te kukū o te whakauru kaha i roto i te ate. I tangohanga nahanaha auau tenei waikawa ate riro te serum tuatahi. kukū waikawa ursodeoxycholic ko e pā ana ki 48%.

Kei te metabolized te pūhui, haere reira i roto i te pūtau ate. Ka rite ki te hua, i hanga glycine me taurine conjugates. E huna ana te hua te pirau ki ate. Mō 50-70% riro excreted te raau taero i roto i te feces. Kei te kawea te nui iti o te raau taero i roto i te kopirua. He te wahia reira e te mahi o huakita (7-dehydroxylation).

waikawa Lithocholic, i hanga nei e tenei tukanga, kua waiho i raro ki te absorption te kanohi o te kōpiro nui, engari haere sulfation i roto i te ate, me excreted rite sulfolitoholiltaurinovogo haumi sulfolitoholilglitsinovogo ranei.

iteraa papû

Medicine "Ursodez" tūtohutia rite te therapy symptomatic mō te cirrhosis biliary tuatahi, kahore tohu decompensation. Whakaatu i te tikanga ki te tareka te reo me nga kohatu cholesterol iti, ki te gallbladder hohe. Kaitūtohu ki gastritis Reflux biliary.

contraindications

'Uhinga e kore e "Ursodez" ako i runga i te tono tukua ki te ūnga ki te wāhanga te rentgenpolozhitelnyh manawanui (te kukū tiketike o Ca2 +) gallstones ātete medicament. Contraindications ngā cirrhosis i roto i te taahiraa decompensation faaite disorders o te repe taiaki, tākihi. tarukino Manakohia hoki te iwi ki kore mahi- tōngāmimi au, whakapeka pathologies inflammatory o tona natura, me te mate whēkau, me te ate tau mahani. Kaua e whakahau rongoā ki hapu, me te mea ngote u. Tikanga contraindicated mō ngā pakeke me ngā tamariki kotahi iti iho i te 34 kg.

pānga taha

I roto i ētahi wā, te whakawhanake pānga e hiahiatia i te tango i te raau taero, "Ursodez". Tohutohu mō te whakamahi whakatupato o te pea o te whakapairuaki, korere, ruaki. I roto i te maimoatanga oneone e taea te hanga gallstones calcified. Amplification mahi ate transaminase, mamae puku, mate pāwera (tae atu urticaria) e hoki houhou hopearaa ingestion "Ursodez".

whakaatu Mua tolerability pai. Kaupapa ki ngā pānga taha prescriptions o te tākuta e pea. I roto i ētahi wā, i roto i te maimoatanga o te cirrhosis biliary kitea decompensation molengofuá. Ka rite ki te tikanga, tenei āhuatanga anake tonu i muri i korenga atu o te tarukino.

Drug "Ursodez". Price. ako

Tikanga tango i te ahiahi. Ko te inenga o ia rā mō te tātau kohatu - he toharite o te 10 mg / kg. No te tangata kotahi ki runga ki te 60 kg hāngai reira capsules 2 ia ra ki te 81 kg- 3-m, 100 kg - atu 4 100 - 5. Duration - i ono marama ki te 12 marama. I muri tātau i te kohatu ki te aukati i te hanganga o te horomanga taunakitia hou mo tetahi marama e rave rahi.

kawea Treatment cirrhosis biliary i roto i te horopeta o 250 mg / ra. Roanga o te akoranga - 10-14 ra. ki runga ki te ono marama. I roto i ētahi wā, kua nui haere te roanga o te therapy ki e rua nga tau. Ka rite ki te maimoatanga symptomatic medicament whakahaere 10-15 mg / ra. A, no te te papatipu ki 34 kg Taunakitia tikanga puka iri. Ko te utu o te raau taero i roto i te puka capsule - i kotahi rau moni.

e te reira i te auraa "Ursodez" ritenga?

Drugs e Kei roto i te taonga kaha taua, hua rawa te rota. I roto ia ratou he mea utu te whakahua i taua tikanga rite "Ursodoksa", "Ursol". Ko tētahi o te rongonui tino ko te tarukino "Ursosan". Tuhinga hoki te whakamahi o te tarukino ko ahua whānui. I roto i ngā, kua whakahaerea taua mea i roto i whēwhē kakakīrehe ate skleroziluyuschem cholangitis momo ma'i.

He hiahia i roto i te faaineineraa te mea pai maha tūroro "Ursodez" ranei "Ursosan". kia mea te reira e kōwhiria e te tākuta kotahi ranei te tahi atu rave'a i roto i runga i te āhua, te akoranga o te māuiuitanga, a faatia i te manawanui te tarukino. I roto i mate o te ate, te gallbladder te kore tino whaiaro tūtohu. I mua tango i tetahi rongoā e hiahia ana koe whakamātautau me te kōrero ki te mātanga.

Te aroturuki i kia kawea te whai huatanga o te maimoatanga i nga 6 marama. I roto i tenei hononga e whakaritea ai he ultrasound auau, me te whakamātautau X-ray i te tuatahi o nga tau o te maimoatanga. Ki te i roto i te marama tuatahi e ono o te whakakorenga o kohatu kihai i tupu, he reira tonu pea o te akoranga koretake e tika ana ki te koretake.

mōhiohio atu

Ki te whakarite i te whakakorenga angitu o kohatu he tika taua mea e nga nga kohatu cholesterol anake, engari e kore e ratou rahi nui 15 ranei 20 mitamano. I te wa ano ki tonu ki te tōngāmimi au kia kaua e neke atu i te hawhe, a kia mau tonu te wahi biliary tona mahi rawa.

I roto i te take o te ūnga roa maimoatanga, neke atu i te marama, he mea e tika ana ki te kawe i roto i te anga matou matüora mō te aromatawai mahi o transaminases i te ate. I tua atu, kia whakahaere i te reira i te kukū o te bilirubin me ētahi atu pūhui. mutu tango tikanga "Ursodez" i te pupuri mahi nui. Reviews o tohunga maha, Heoi, he pai e pā ana ki te whai huatanga o te tarukino.

mutunga

Ki te taea te whakaritea kore hua ki tetahi atu medicament rautaki maimoatanga ranei rawa hou. I mua i te whakamahi i te hua kia kia waia ki te Tuhipuka.