"Pradaksa" - analogues. "Fafati", "Ksarelto": arotake, utu

I roto i āpiha antithrombotic whakamahia ki te tango i te thromboembolism i roto i te uaua i muri i te pokanga, whakaatu ana te tōtika tino faaineineraa "Pradaksa". Ko tōna analogues whai tohu whānui mō te whakamahi, me te i roto i te hanganga i rerekē kai kaha. E wātea ana i roto i Anticoagulants puka inenga mārō ki toketaá rerekē.

Whakaahuatanga "Pradaksa" tarukino

Manufacturer antithrombotic me anticoagulant rongoā "Pradaksa" he kamupene "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". tikanga wātea i roto i te capsules pakeke, i roto pire roto iti kōwhai. Ko te kaha etexilate rawa dabigatran whakaaro puka tautauā, te maha o e whakatau te inenga o te rongoā. pea te reira i 75 mg, 110 mg me 150 mg.

He aha te tarukino "Pradaksa" whakamahia te

hono te whakaaro matua o capsules te ki te ārai o te thromboembolism venous i muri tari pokanga i roto i te pūnaha musculoskeletal.

Kia pehea te te taputapu "Pradaksa"

Kei te whai pānga te reira ki te pehanga o te huarahi mahi thrombin o mahi o taero "Pradaksa". whakaatu Analogs āhuatanga paku rerekē. Te riroraa i te rāpoi ngota iti dabigatran etexilate, e kore mahi pharmacological.

tomo anake te tinana tangata, wahia te taonga kei te i muri i paparetanga ki te dabigatran free e kaha inhibitor whakataetae hāngai reversible o thrombin whākōkī. Kei te here te tūranga o te thrombin ki pūtōtepe, thrombin, whakaiti whakawhāititanga pūtau o mōtepe meinga e te mahi thrombin.

enei taputapu

Whai tarukino "Pradaksa" ritenga. Otiia i roto i tona hanganga, e kore e dabigatran etexilate roto i ratou, kua whakakapia reira ki ētahi atu āpiha anticoagulant. Ko te kupu, ko te kaha tikanga rite whakauru "fafati" he warfarin, i roto i te medicament "Ksarelto" kei rivaroxaban. faaineineraa taurite "Pradaksa" tika "Marcumar" me "Fenilin" ngā phenprocoumon me phenindione te whakaatu i.

Whakaahuatanga "fafati" tarukino

Kua kua whakarārangitia matou, e whai i te tarukino "Pradaksa" ritenga. Kia whakaaro inaianei tatou i roto i atu taipitopito tetahi o ratou.

hua te medicament "fafati" kei roto i te puka o papa ki te inenga o te whakauru kaha, 2.5 mg. Ko te kaihanga o te tarukino ko te kamupene Russian "Kanonfarma production."

He atu inenga (1 mg, 2 mg, 3 mg me 5 mg) ke rongoa hāngai warfarin. he rerekē i tetahi taha o te horopeta tīpakongia i roto i mg te āhua, te tae me te rahi o nga papa.

He aha whakamahia te raau taero e

Reception "fafati" he ka taea:

• Thrombosis o te pūnaha venous predisposition ranei;
• mo te maimoatanga prophylactic o Thrombosis me thromboembolism;
• i roto i te Thrombosis venous whakapeka i roto i, me te Embolism i roto i te kiko pūkahukahu;
• i Thrombosis postoperative;
• whakapeka uaua ngakau myocardial;
• i roto i te pokanga me te therapy thrombolytic o Thrombosis;
• ki te whakaeke rere pūroto rangitahi;
• hoki maimoatanga auroa o te Thrombosis venous recurrent;
• i roto i te piha prosthetic i roto i te ngakau.

Kia pehea te te kaihoko

āhuatanga motuhake o te mea "warfarin" whakaiti āhuatanga upoo- toto tautāwhi i te hanga o (X, IX, VII, II), huaora K-ti'aturi toto, me te take coagulation. E synthesized ate pūmua Anticoagulant C me S ki te whānuitanga iti i raro i te mana o te tarukino. te whakaiti i tenei katoa i te hanganga o te clots toto e arahi ki te hanganga o clots toto.

Hei whakakore tākuta Thrombosis venous whakahau maimoatanga ki anticoagulants autaki. e kore anō-whakawhanake tenei Thrombosis, e taea meinga pōauautanga.

Tātaitanga o te horopeta o warfarin i reiti rerekē INR

Wāhui "fafati" taea i muri i te whakamātautau taipitopito tarukino, i roto i nei tāutu contraindications katoa. Ko te tātaritanga mō te maimoatanga anō tīpakohia te nui e hiahiatia ana o medicament "fafati". Ko te horopeta ia ra e kore e nui 5 mg o te taonga kaha matua. Ki te pānga haumanu iti o te maimoatanga kawea i roto i te ako. e tūtohu ana ki te tuhi i te horopeta riro, INR taumata me te pānga e puta mo te tātari o te therapy.

I raro i te INR (ōwehenga tonu o te ao) fakahu'unga paerewa mō te whakatau i te mahi o ngā huānga toto upoo-. whakaawe āhuatanga toto upoo- te uara o te tohu. He mea nui ki te aroturuki i te INR ka te fariiraa "warfarin" e fakafuofua e te mea inversely hautanga ki te upoo- toto. Ko te kupu, i te ōwehenga tonu o tiketike pōturi upoo- me whakanuia ana hypocoagulation.

A, no te kia aroturuki rerekē āhua i etahi INR.

1. Hoki te rauropi hauora, tona täkupu e ko e pā ana ki 1.0 (ranei deviates paku - i 0.85 ki te 1.25).
2. Ma'i fibrillation Atrial ka fariiraa i "fafati" pire me haere tahi e te ōwehenga tonu o o 2.0 ki te 3.0 wae.
3. prosthesis takirere Mechanical āhuatanga e te INR o 2.0 ki te 3.0, te prosthetic mīhini piha mitral i 2.5 ki te 3.5.
4. I roto i te maimoatanga o thromboembolism i roto i te iatuku pūkahukahu me etahi kohakore ngakau Me te taupū taumata o 2.0 ki te 3.0.
5. Kia kore ai Thrombosis i roto i te uaua hohonu i muri i te pokanga me mo te maimoatanga o te Thrombosis venous, piri ki ngā uara o 2.0-3.0.

kia te tarukino "fafati" kia kawea atu ki aroturuki tupato o te taupū INR me tino te tirotiro hauora, ki te taea ki te whakatika i te inenga. kawea stabilization ōwehenga tonu o me te kōwhiringa o te nui e hiahiatia ana o medicament te i hoki e pā ana ki kotahi wiki, a ka nga 4 wiki takina tenei uara te.

Hei haere mai i te pānga o te tono o "fafati" o te raau taero, me pehea ki te tango atu i ki horoi iho me ranei te huinga o te kai, e hiahia ana koe ki te mohio. inu rua papa he ra, e kore te whakakotahi ki te kai o te kai. horoi iho ratou ki te wai, me te mau i te wa ano. I tua atu, kia waiho te tuku o tätari i runga i te INR i roto i te taua haora, me te i roto i te taiwhanga pūmau. A, no te e mokowhiti ana pota e tika ana ki te kawe i te wahi i muri o te wa fariiraa.

I reiti iti iho i te 2.0 INR whakaaro te toto matotoru, he whai hua te tarukino, reira, he mea e tika ana ki te whakamahi i te teitei inenga "warfarin".

I roto i ngā o neke atu i te 3.0 INR kua whakaaro reira toto wai, kia puta toto, koia ko reira tika ki te tono i te iti rawa inenga tiketike o te tarukino.

Ko te utu o te rongoā "fafati"

I roto i rite ki te tarukino Tiamana "Pradaksa" tona ōrite Russian o "fafati", te utu o te mea i te 80 moni ia mōkihi, ko reira nui ngawari te me atu wātea.

Whakaahuatanga "Ksarelto" tarukino

I medicament kia "Pradaksa" analogs ki ngā āhuatanga anticoagulant, he mana tika. tarukino "Ksarelto" e pā ana ki a ratou. whakaputaina te reira i te reira i roto i te puka o tawhio kiriata papa pani i roto i te kamupene German "Bayer".

Ko te hanganga e rivaroxaban i roto i te puka micronized. Papa "Ksarelto" kei roto i te toketaá e whai ake nei: 2.5 mg, 10 mg, 15 mg me 20 mg.

tikanga o te mahi

tuku Rivaroxaban ki rite tino whiriwhiri take tika Xa inhibitors e whai bioavailability nui kitea i muri i whakahaere-waha.

i hanga te Niniiraa coagulation e te faaitoitoraa o te tauwehe X, kua tahuri nei, e tika ana ki roto, o waho ara coagulation ki tauwehe Xa. whai wāhi ana tēnei wae e i roto i te hanganga o te pūhui prothrombinase i te mahi o nei te tahuri te prothrombin ki thrombin. Ēnei tukanga hanga he katinga pūtōtepe, ka whakahohetia platelets. He he he "pakaru" i roto i nei e tika ana ki te take e synthesized Xa muingota ki tetahi mano o enei pūtau toto.

Mā te inhibitors whiriwhiri e whakaiti mahi activator puta mutu "pahūtanga thrombin". Mahi rivaroxaban whakahaua ki te huri i te hua o te tātaritanga taiwhanga motuhake whānui ranei i te āhua o te pūnaha coagulation tata. mahi Factor Xa rerekē i runga i te horopeta inhibitor, e te kaimahi rite te tarukino "Ksarelto" (15 mg o papa ranei ētahi atu inenga reira).

tukinotia e te ki tenei tarukino

whakaahua ana i te buka haapiiraa i te whakamahi o te medicament mo te ārai o te mate i muri i mate Cardiovascular e pā ana ki myocardial uaua ngakau , me te whakapeka syndrome coronary. Medicine "Ksarelto" whakawākanga pūāhua pai whiwhi hoki te therapy huinga whai hua i roto i te taha ki te ahipirini ahipirini ranei me thienopyridine.

Me pēhea te ki te tango i pota rerekē o te tarukino

tikanga te tarukino te mo te whakamahi ā-. Papa pota katoa tangohia ki kai.

I roto i te tikanga ki te whakakore i syndrome coronary whakapeka e tohutohu ki te tango tetahi papa o 2.5 mg rua he ra. Fakataha ki te faaineineraa "Ksarelto" (whakaatu whakawākanga te whai huatanga o te whakamahi i ona he huinga taua) e taea te whakahaere te waikawa ahipirini i roto i te horopeta rā o i 75 ki te 100 mg, me te huinga o te ahipirini me clopidogrel i roto i te nui o 75 mg ia ra. Me whiwhi tēnei therapy te tirotiro hauora tonu mō te haapa'oraa o te toenga, wāhikē nei ki tetahi taha e taea meinga raruraru rere pūroto toto ranei. Ka mau i te tarukino roa, me te e pā ana ki te kotahi tau, i roto i te tahi mau tūroro ki runga ki te rua tau.

Ko te papa i roto i te inenga o te 10 mg rivaroxaban tango tetahi wa he ra. Ko te inu tuatahi i muri i 6-9 haora o mara pokanga ki hemostasis whai hua. whakaritea te roanga o te maimoatanga e i roto i te rahinga taua o te tarukino mo ia manawanui takitahi, i runga i te mōrea o venous thromboembolism, whīwhiwhi me te momo o te mahi rānei.

A, no te te whakahaere tarukino wā "Ksarelto" whakakapinga hip (10 papa mg) pumau ki runga ki te 5 wiki, i roto i turi arthroplasty riro te reira 14 ra.

Ki te mea kua wareware te manawanui ki te inu i tetahi horopeta o rivaroxaban, kia pau tonu reira, me te ra i muri ki te haere tonu i te maimoatanga, 1 papa.

e kore hoki toketaá Higher o 15 mg 20 mg ranei tango i runga i te puku kau.

I roto i te tikanga ki te ārai i te āhua o te patunga me te pūāhua Embolism pūnahanaha ki kore-valvular fibrillation Atrial tūturu ngakau Atrial te whakamahi i tetahi papa horopeta o 20 mg kotahi te ra.

I roto i te täkihi, ka te auau o te creatinine whakakorenga hawhe-ora o iti iho i te 30 ml mo te 1 meneti, te whakamahi i te horopeta o 15 mg 1 wa ia ra.

Ko te roanga o te maimoatanga tei runga i te aroaro o te riri o te Stroke me kāwanatanga thromboembolism nahanaha.

E kore e te inenga o ia rā e mama mōrahi e neke atu i te 20 rivaroxaban mg.

Thrombosis, rua hohonu e pa ana, mo te ārai o hohokitanga o te mate me te thromboembolic e pā te iatuku pūkahukahu, te whakamahi i te horopeta tuatahi o 15 mg rua he ra i roto i te wiki tuatahi e toru. Muri neke ki nga papa o te 20 mg rivaroxaban kotahi te ra mo te maimoatanga wā roa-a te ārai o te re-Thrombosis me recurrent Embolism pūkahukahu.

Ehara i te mea i nga wa katoa e taea ana ki ki tūroro horomia te papa katoa, rawa he rahi nui, ka te whakaaetia ai ki huri me te ranu ki te wai parakore ranei te kai wai i mua i te kohi. i muri tonu tango i te raau taero e kai i te manawanui.

Ko reira taea hoki ki te whakauru i te pire mongamonga e gavage, te tūranga o nei i roto i te pūnaha kūnatu ruruku te i roto i te mua ki tō tākuta. Ngā hanga papa mongamonga i roto i tenei ara ngā i roto i te ranu i te tarukino ki te nui te iti o te wai, me te muri ki te whakahaere. I muri i taua ki tonu i te te wai iti ki te tango toenga tarukino i te uiuia. I muri i te rongoā e tika ana ki te kawe i te horomanga kai enteral.

Ko te utu o te tarukino "Ksarelto"

E pā ana tēnei taputapu ki taero kawemai ki te utu nui. Hei tauira, ka hei te tarukino "Ksarelto" utu o te horopeta iti i roto i te 56 pire o e pā ana ki 950 moni. Ko nui atu te utu atu i tona orotahi Russian reira - rongoā "fafati". I roto i te rongoā "Ksarelto" piki utu i runga i te hua i roto i te inenga. Ko te kupu, ko te uara 14 papa o 15 mg rivaroxaban ka waiho e pā ana ki 850 moni, i te pikau (28 nga wahi o papa) ki te horopeta teitei (whakauru kaha 20 mg tino) e utu 1450 moni.