"Probenecid": tohutohu mō te whakamahi, analogs, arotake

He aha te mea he tarukino "Probenecid"? Ka kia whakarārangitia tohutohu mō te whakamahi, taurite, ritenga me tohu mo te whakamahi o te raau taero i raro.

Puka, hanganga

He aha te mea probenecid? Tohutohu i runga i te tono o ngā kerēme, i te mea he taonga kaha kitea e te i roto i ngā hua maha. Ka taea e Hoko taua rongoa kia i roto i tetahi rongoā i te utu utu. Ka taea te hua ratou i roto i te puka o papa, capsules, a tae noa paura mo te whakatārewatanga.

Ko te mahi pharmacological o te tarukino

tarukino "Probenecid" pehea e mahi i te reira? Tohutohu mō te whakamahi, titau arotake reira arthrifuge i te mea nehenehe ki te tautāwhi i te reabsorption o mua i roto i te tubules tākihi, a tino whakarei tona excretion.

Kōrero ngaio hua nui i roto i te excretion o mua i raro i te mana o te taonga i roto i te pātai kia whakapiki ake i tukanga i tophi tona tuku ki te bloodstream, e meinga te mutunga te whanaketanga o te whawhai whakapeka o kauti.

Ano, te tarukino "Probenecid", tohutohu hoki te whakamahi whakaahuatia nei te raro, maha arata'i ki excretion whakaroa i nga whatukuhu o te tahi atu raau taero na roto i te whakanui ake i to ratou kukū i roto i te wē. Tenei ka taea te whakamahi o te moni hei rongoā atu i roto i te therapy paturopi.

āhuatanga nekeneke

he rongoa "Probenecid" ngote? Kia roto te tino whenumi ai i te wahi gastrointestinal. tutuki te kukū tihi i roto i te toto o te probenecid te i muri i toru haora, me ona pūmua here ko e pā ana ki 85-96%.

Hea wāhinga o te tarukino i raro i whakaarohia? E ai ki nga tohutohu, kua metabolized reira i roto i te ate. ngā tenei te atsilglyukuronidny taketake, me te tahi atu metabolites.

Probenecid he putanga i te secretion kaha i nga whatukuhu tubules proximal me filtration glomerular. I roto i te mimi o te manawanui kitea te pā ana ki 75-86% o nga metabolites, ka excreted te toenga kei te tonu i roto i (i runga i te auau rere o mimi, me te kawatanga).

iteraa papû

E akono mate o te tarukino "Probenecid"? Tohutohu mō te whakamahi tohe e he whai hua i roto i te hyperuricemia tenei kaihoko faaite ake therapy mō te kauti ma'i, me te hyperuricemia te whakamahi i Diuretics.

E kore e taea e tatou te mea e rite hei atu tikanga o tenei rongoā whakaritea te mo te maimoatanga o penicillins rongoā paturopi me cephalosporins.

contraindications

I roto i ētahi wā, rāhuitia reira ki te whakamahi i "Probenecid"? Tohutohu mō te whakamahi e pā ana ki taua contraindications o te raau taero, pērā i:

• porphyria;
• whakaeke whakapeka o kauti;
• i roto i te hapū;
• urolithiasis (tae atu i te aroaro o te kohatu urate);
• Tamariki raro i te rua tau o te tau;
• ine i roto i nga tätari o toto piringa;
• hypersensitivity ki probenecid;
• hyperuricemia tuarua meinga nei e te whakamahi o āpiha chemotherapeutic tukanga puku ranei.

Medicament "Probenecid": tohutohu mō te whakamahi

Ka kia whakarārangitia analogues o tenei taputapu i raro.

I roto i te raau kauti ma'i kia tangohia i raro i whakaarohia i roto i te horopeta o 250 mg rua he ra mo te kotahi marama. He wiki i muri i te tīmatanga o te maimoatanga he mea taea ki te whakapiki ake i te maha rite rua.

I roto i te take o te pānga haumanu iti o te horopeta e taea te nui haere nga marama i runga i 500 mg. Kia mahara te reira e te horopeta mōrahi o te medicament ko 2 g he ra.

Ki te i roto i nga marama e ono e kore e te manawanui i tetahi whakaeke whakapeka o kauti, a kahore e taumata urate toto nui tīkina, ka te nui tohua o te tarukino e taea te āta heke ki te whai hua iti (hei tauira, i 500 mg nga marama e ono).

kia nui haere ai te inenga o te iwi probenecid te whiwhi Diuretics pyrazinamide ranei.

A, no te mau ana i roto i te maimoatanga o te teuteu rongoā paturopi paturopi, me te cephalosporin tūroro pakeke pūrongo rongoā whakaritea ki 500 mg wha nga wa he ra.

I roto i ngā tamariki pakeke e rua nga tau, kia horopeta tuatahi o te medicament 25 mg ia kg taimaha tinana, aru e te whakanui ake ki te 40 mg ia kg. Ko te wā wā i waenganui i pota o te tarukino ko 6 haora.

I roto i te tikanga i te maimoatanga o te gonorrhea "Probenecid" ka whakamahia i roto i te inenga o te 1 g ia te hawhe haora ki te whakahaere parenteral o te rongoā paturopi.

pānga taha

He aha e nga tauhohenga o te pūāhua kino taea meinga rongoā "Probenecid"? Ko te Ture apitiria ki te tarukino, ki te tohu i te pānga taha e whai ake:

• minamina, anorexia, syndrome nephrotic, ngā pae nui;
• ānini, kirika, whanoke;
• urticaria, whakapairuaki, urination auau, ruaki;
• leukopenia, Stevens - Johnson, necrosis ate, alopecia;
• anaphylaxis, dermatitis, anemia, me tai;
• anemia hemolytic, ähua o te kauti, anemia aplastic.

taunekeneke tarukino

E ai ki te ako, he taonga kaha taua, pērā i probenecid, taea whakapōrearea excretion me te whakapiki ake i te kukū i roto i te toto o taua rongoā rite "Captopril", "Acyclovir" conjugates sulfonamides, "Paracetamol" sulfonylureas "naproxen", aminosalicylates, "Methotrexate" "lorazepam", "meclofenamate", "Rifampicin" "Indomethacin", "azt" me "Ketoprofen".

mōhio hoki e whakaiti te raau whakaaro te kukū i roto i te mimi me te penicillamine nitrofurantoin e whakaiti ratou pānga haumanu i cystinuria me mate mimi, aua.

Ko te medicament "Probenecid" ai he hua i roto i te excretion aminogippurovoy fenilsulfontaleina waikawa, waikawa 5-hydroxy-indoleacetic, me sulfobromftaleina me excretion iti o metabolites o hormones pūtaiaki i roto i te mimi.

mōhiohio tauwhāiti

He aha kia mohio koutou i mua i te whakamahi i te tarukino ki probenecid? E ai ki nga tohutohu, e kore e tūtohutia taua taka hoki te whakamahi i roto i te hyperuricemia tuarua meinga nei e tukanga tumoral te whakamahi o āpiha chemotherapeutic ranei, rite mea e kore e rawa whakaiti i te kōtuitui o mua, me te faarahi anake tona pūnaha excretion tākihi. Whakawhanake i te hyperuricosuria wa ano kia whakanui ake i te mōrea o te nephropathy.

Ki te tūpato tino kia whakamahia pūrongo tarukino hoki te iwi ki te mate whewhe keté, me te ma'i täkihi. I roto i te take whakamutunga, kia kia koretake probenecid.

A, no te whakamahi i tenei medicament mo te maimoatanga o te kauti ma'i kia whakawhanake tona whawhai whakapeka, ka nui haere te tipu o te calculi tākihi.

Iwi ki te G6PD hē kia meinga anemia haemolytic.

Overdosing probenecid meinga CNS whakaongaonga, whakatairanga haurangi, a kia arahi ki te mate e tika ana ki te kore romahā.

He mea tika ki te karo i te fariiraa tukutahi ki probenecid "ketorolac" me salicylates.

People tango tenei tarukino, titau iti inenga "thiopental" mo whakahaere o rehunga.

I roto i te tono whakarara o methotrexate me probenecid horopeta tuatahi kia heke i roto i te tikanga ki te whakaiti i ona pānga taha.

I tango tenei tarukino taea hua pai teka i runga i te whakamātautau kūhuka mimi.

Analogues, taurite

Ka taea te whakakapi i te tarukino e "Probenecid"? Ka taea te hokona analogues o tenei taputapu i tetahi rongoā. Ko ētahi o ēnei i te whai ake: "Phytolysinum", "Tsitrokas", "Uronefron", "Uroholum", "Baytach", "Cystone", "tatūtangā", "phytol", "Urohol" me etahi atu.

Ko taurite, e pā ana te tarukino pēnei ki a ratou rite "Santoor".

Reviews o arthrifuge

Kia aroha mai, arotake kiritaki, "Probenecid" takanga, e kore he tino nui i reira. Heoi, hira ka he karere "Santoor". titau Tūroro e te pai whakakitea te raau taero i roto i te maimoatanga o te hyperuricemia i roto i te tūroro ki te mate kauti ma'i, me te hyperuricemia ina whakamahi i Diuretics. Hoki ko reira he kaihoko whakaora pai mō te cystitis whakapeka kitakita, urethritis nonspecific, postoperative mate roma mimi me ētahi atu raruraru urological.

E kore e taea e kore ki te whakahua i te meka e te pūrongo o rongoā i reira e ano taha kino. Kiritaki ratou ngā maha rawa ngā pānga taha me contraindications.