Te raau 'Manini': tohutohu mō te whakamahi

whakaahua ana faaineineraa "Mannino" ā-ako tarukino antidiabetic rite whai hua e te rēhita Inn (International Nonproprietary Ingoa) ingoa ko "Glibenclamide". Tenei taonga ko te kaha matua i roto i te faaineineraa, whakaputaina nei e kaiwhakanao i roto i te puka o papa, kotahi 1.75 mg 3.5 mg ranei. Ko te hanganga tarukino rite pūhui pŭpŭ tauturu ngā ano monohydrate reihuka, takawai, kai tāpiri E 124 - 'cochineal' waikano, māngaro potato, gimetelloza.

Ko te āhuatanga pharmacokinetic o te raau taero e whakaratohia ana e glibenclamide - roto te roto i te waihanga i roto i te puka micronized - matua taonga kaha. hanga tenei reira taea ki te whakapiki ake i te auau kătahi o te tarukino me te whakapiki ake i te rohe o tona momi. Ano, absorption whai hua atu o te wae tarukino whai wāhi methylhydroxyethylcellulose, i te mea wahi o te faaineineraa "Mannino".

Ka whakamōhio ngā tohutohu mō te whakamahi i te tāpiri tata kore pānga i runga i te āhua o te tinana, engari, ahakoa, hanga ana e ia taea rawa tino whakanui i te wa noho o te wāhanga o te raau taero i roto i te wāhanga dispersed, te hua tino mo ona mahi. I roto i tenei wā te kukū o te tarukino i roto i ngā wāhanga wē faarahi e toru ki te rima nga wa, ko te kupu i reira ko te whakaiti nui i roto i te nui o te kūhuka.

Medicament "Mannino" faaite tikanga aratohu e rua he te taonga tere whenumi i te wahi gastrointestinal me ona ahua micronized o glibenclamide Mā rawa tukua i te pūhui pŭpŭ tauturu i roto i te tinana mō te rima meneti. hanga ana tēnei pānga e taea ki te tango i te tarukino i mua i tika i te kai, mo te 5 - 10 meneti i mua. puta te kukū tihi faaineineraa mua, me ona mahi, reira, he mea whaiaroaro. Ahakoa i roto i te parau tumu, e kore e te fariiraa tukutahi o kai i nui pānga i runga i te mahi o te tarukino. Te faaineineraa "Mannino" kua he taumata o 100% bioavailability. Ko tōna hawhe-ora o te kaiao ko te toharite o tetahi, me te hawhe ki haora e toru me te hawhe.

tonu Time pūmau pānga hypoglycemic o glibenclamide te puta noa te ra.

Ko te āhuatanga pharmacodynamic o te tarukino, whakaahua ana "Manini" ā-ako i roto i tenei ara. Medikamet tenei kia whakapai ake i te secretion o te taiāki huka ina whakarei ake momi i te pūtau beta o te repe taiaki, me te raau taero taiāki tūtohutanga, tutuki nei i whakaongaonga o te receptor taiāki.

I tua atu, e taea ki te whakaiti i te mahi o te mōtepe ārai ischemia myocardial glibenclamide ko. Te raau hoki kua he mahi ārai ki arrhythmias cardiac.

Ka rite ki te pai whakapumautia, te raau reira whakaiti nga tūponotanga o fifi o te mate huka (momo 2), e ngā mate huka cardiomyopathy, nephropathy me retinopathy. whakaahua ana Medicine "Mannino" ā-ako rite te tikanga o te whakaiti i te taumata o te tahuti nei i roto i mate e pā ana ki te mate huka.

Ko te tohu matua mo te whakamahi o te glibenclamide - mate huka o te momo tuarua, ka whakakitea kai therapy te putanga ta'efakafiemālie. Papa "Manin" taea te whakamahi hei kaihoko whakaora motuhake, me hei wāhanga o te ngā therapy ki ētahi atu rongoā anti-huka.

kia whanau te reira i roto i te ngakau e te roanga o te rongoā me te horopeta o te uara i whakaritea e te rata e hāngai ana i runga i te huarahi takitahi ki te manawanui. I te wāhanga tuatahi o te maimoatanga whakaturia pota iti o whakahaere tarukino. Na, he aratau ako o tono, tahi ki te ako o te kai. Taipitopito o horopeta talena whakaahuatia te i roto i te tohutohu mo te whakamahi o te raau taero.

Ko te paearu matua mō te horopeta whakatikatika te taumata o te kūhuka.

Te fariiraa i glibenclamide kia meinga pānga taha, te tino noa o te mea e suka. Ko tōna tohu ko te sweating huaki tata, faaati, ānini, disorders neurological, me ētahi atu.

Contraindications mō te whakahaere o te tarukino he hypersensitivity ki te wāhanga inefficiencies maimoatanga tuarua ki "Mannino", ketoacidosis, disorders mahi o nga whatukuhu, me te ate.

Kāore i te nui ngā kōrero i runga i te whakamahi o te tarukino e kore e nga tamariki, nei tau nui 18 tau.

Kaua e whakamahi i te rongoā i roto i te whāngai ū me te i roto i te hapū.

Rokiroki i te tarukino me waiho i te pāmahana o te kore neke atu i te 25 C. I roto i nga tikanga o te rokiroki papa ora o te tarukino ko 3 tau.