Ko te tarukino "Avastin": mua manawanui, tohutohu mo te whakamahi, ngā pānga taha

whakaaro te tarukino "Avastin" ko te kaihoko antitumor, e pā ana ki paturopi monoclonal. I roto i te tono o te tarukino ko te haereraa heke o te mate metastatic me microvascular uruhanga i roto i te pukupuku mārere o ngā momo, ngā hunga e pā ana ki te uma wahine, kopirua, me taiaki me te repeure.

te raau taero

Wātea tarukino "Avastin" i roto i te puka o te kareti tikanga nei ki te faaineine i te otinga mō te whaowhia kia taekore ranei paku hāurakaho rangona.

Ko te taonga tarukino taketake he bevacizumab. E wātea ana i roto i te pōkai o 100 mg te taputapu, me 4 ml o te taonga kaha, me te 400 mg / 16 ml.

pānga pharmacological

"Avastin" - ki puku raau e inhibits te hanganga o oko toto hou e tuku hāora me ngā matūkai ki te kopa neoplasms me reira taea whakawhiti o te mate pukupuku kaitaua i roto i te wā tonu. "Avastin" (whakautu o tūroro me rata - tohu) mahi nuinga i roto i te metastasis o ngā pukupuku mārere.

Hoki te āhuatanga tenei taputapu e te nui iti o horapa i te tinana, i roto i te tua, ko reira roa nui nekehia i te tinana, e taea ana ki te mau tonu te nui e hiahiatia ana o te wāhanga matua o te tarukino mā te injecting reira tino rite ki tohutohu - kotahi i roto i 14-20 ra. e kore te mea ahu hua rongoa i roto i te ate whatukuhu ranei, a i roto i ngā pūtau katoa o te tinana mo te ra 18 mō te tangata, me te mo nga wahine - 20.

Ko he pai "Avastin"? Mua mea e ko te tarukino rawa whai hua tenei, ki te ngā koe i te reira ki te hahau i ngā momo rerekē o te pukupuku. tikanga o tēnei tino faarahi te wā ora o tūroro i roto i ngā rōpū katoa, me te ahunga whakamua o te mate puta.

"Avastin": tohu hoki te whakamahi

Kei te whānui whakamahia tenei tarukino i roto i te therapy mate pukupuku. Doctors whakahau reira:

1. I roto i te metastatic mate pukupuku colorectal. Kei te tūtohutia te tarukino mō te whakamahi i roto i te taha ki te hahau e hāngai ana i runga i 'fluoropyrimidine'.
2. I roto i te mate pukupuku uma metastatic. Kei te whakamahia te reira i rite te rārangi tuatahi o te maimoatanga i roto i te taha ki te "paclitaxel".
3. A, no te mahi tika, tahi e te maha nui o metastases neplosko-, kore-iti pukupuku pūkahukahu pūtau ranei - rite te therapy raina tuatahi i roto i ngā ki te hahau konukawata hāngai taka rongoā.
4. I roto i te mate pukupuku matatau metastatic ranei, e pa pūtau tākihi - hei kaihoko mō te therapy tuatahi i roto i te taha ki "Interferon Alpha-2a".
5. A, no te glioblastoma roto i te taha ki te radiation therapy, me 'temozolomide' i roto i tūroro e hou pāngia, i roto i te monotherapy ranei i roto i te taha ki "irinotecan" i roto i te tūroro ki te glioblastoma recurrent haereraa mate pukupuku ranei.
6. Tūroro e pāngia ki "puku mārere o te Rauakitua taihemahema wahine", me i roto i te mate pukupuku peritoneal tuatahi. I roto i tenei take e tūtohu ana ki te tautapa i te tarukino "Avastin" rite te therapy hauora tuatahi i roto i te taha ki "carboplatin" me "paclitaxel".

I tua atu, whakahaere he tarukino ki "carboplatin" me "Gemcitabine" hoatu hoki te mate matatau tairongo ki āpiha e hāngai ana konukawata-ki te tūroro ki te mate pukupuku o te whekau wahine taihemahema te peritoneum ranei, kihai i i i tukinotia e te taputapu, tetahi momo o te inhibitor o VEGF ranei ranei.

Me pēhea te ki te tomo "Avastin"?

"Avastin" (whakautu o tūroro me ngā tākuta whakau reira) - he tarukino pai, engari me tika kia whakahaerea taua mea, a anake i raro i te mātakitaki o taote. Kei te tino riria ana te reira ki te tomo i te jet - pâmuhia anake, a ka rite āta rite taea. Ko te tātai, ko te 5 mg ia 1 kg o taimaha tinana 1 te wā i roto i rua wiki.

diluted te nui e hiahiatia ana o kareti kei roto i te 100 ml 0.9% konutai pūhaumāota. tūtohutia te horopeta tuatahi te ki te tomo haora kotahi me te hawhe i muri hahau, mahi werohanga atu o "Avastin" te i mua i muri i te tukanga ranei. Ki te te whakahaere tuatahi o te tarukino i te manawanui kahore pōauautanga, te atu taea te whakahaerea i roto i te haora, me werohanga muri katoa - mo te hawhe haora, engari anake te mea te tuarua kua pai whakawhiti hukihuki mate.

e kore e tūtohu noa horopeta ki te whakaiti i te aroaro o ngā pānga houhou, ki te tika, whakatarewa ranei mutu te maimoatanga.

Ki te mea kua kua kitea te manawanui pukupuku metastatic colorectal, te horopeta tuatahi tūtohutia o 5 mg ia kg taimaha kotahi nga ra 14 7.5 mg / kg ranei te tinana, engari i muri i nga ra e 21. Ki te he therapy raina tuarua, nui haere te inenga e 2 ngā wā.

Ki te pāngia tetahi wahine ki pukupuku o te uma, i roto i tenei take, tūtohutia te werohanga tuatahi kei e ki te waihanga o te 10 mg / kg me te kawe i roto i te werohanga katoa e rua wiki. Ranei e toru, engari i roto i tenei take e riro te reira ki te 15 mg ia taimaha tinana kg.

Ki te mea i reira he tohu o te ahunga whakamua o te mate, kia mutu maimoatanga.

Ki te whānui mahi tika, recurrent, metastatic pukupuku pūkahukahu pūtau neplosko- ranei kore-iti i roto i te maimoatanga ranei kawea i roto i roto i te taha ki te taero hahau Pt (kaua e neke atu i te 6 huringa), me muri i whakamahia te tarukino rite monotherapy.

Me koe ki te mutu ki te tomo "Avastin" ka kite koutou i nga tohu o te haereraa mate pukupuku. Tohutohu mō te whakamahi āhua ki te kahore haereraa, te tātai, ko te 7.5 mg / kg nga ra 14 nui haere te inenga e te hawhe, me te te whakahaerea kotahi nga wiki e toru i roto i te tua ki te "cisplatin" me "carboplatin" ranei.

I roto i te pukupuku pūtau tākihi horopeta e kore e nui 10 mg / kg mō te 15 ra kotahi. Ki te mea i reira he tohu o te haereraa o te mate, kia mutu te maimoatanga.

e kore e hiahia ana te iwi pakeke ki te whakatika i te horopeta.

"Avastin": tuwhena rawa

puta tino pinepine Drug tuwhena rawa i roto i te hui i kua he manawanui kua whakaritea horopeta tiketike - 20 mg ia kg manawanui taimaha tinana katoa 14 ra.

I roto i tenei take, kia puta whakaeke migraine i roto i te puka tika matatini, i roto i te tua, kua reira kua piki haere ngā pānga kino whakaahuatia i raro nei. raau Special Kāore i te tīariari, whakamahia anake therapy symptomatic te.

"Avastin": pānga taha

"Avastin" - he tarukino rawa pai, i roto i te nuinga o te wā e tauturu te reira ki te pōturi te ahunga whakamua o te mate nui, engari kei te kitea maha tūroro pānga houhou. I roto i te wā onge, e taea e ratou rawa nui:

1. Perforation o te puku , me te paru.
2. toto ā-.
3. thromboembolism matua.
4. pēhanga toto nui ake, me te proteinuria whakawhanake. Te nuinga pea, ko te putanga o te whakautu horopeta manawanui tenei.

I tua atu, tūroro nei i whakaritea i tarukino "Avastin", pānga taha me ētahi atu tohu puta:

• Thrombosis rua hohonu, he ahua matatini o te kore ngakau, tachycardia supraventricular, toto;
• leukopenia, neutropenia, iti thrombocytopenia pūtoto;
• hūhi i roto i te peritoneum, disorders puku, toto i roto i te kumete, he ohorere ma'i i roto i te mangai, toto pae, whēkau tutukitanga waewae;
• toto i te ihu, te kore o te hāora, thromboembolism pūkahukahu;
• kiri maroke, dermatitis, reo kiri;
• mate o te reka, te mate taimaha tere, syncope, migraine, patu, te momoe;
• atarua;
• mamae i roto i te wahi i reira faaterehia te medicament te;
• toto i te kōpū, mate roma mimi, he tikanga o te rohirohi, maroketanga.

contraindications

Ahakoa e tika ana katoa "Avastin"? Mua mea e ko he tarukino pai tenei, engari ahakoa ano hoki te reira he contraindications ki te whakamahi, me te aroaro o te tīmata koe maimoatanga, me korero i te tākuta koe e pā ana ki a ratou. e kore e kia whakaritea te tarukino i roto i te wā e whai ake nei:

• ki te mea i reira te mea he ātete motuhake matua whakauru kaha;
• He mate hopuhopu o te kanohi, me te wāhi periocular;
• puta mumura Intraocular;
• tau o 18 tau;
• Pregnancy me te hohipera.

I tua atu, ki te he te tupono o patu te manawanui, ka hukihuki "Avastin" hoatu anake i muri i te manawanui āta titiro me te haere mai ki te mutunga e te painga tarukino.

Ara

tarukino whāki i kia tākuta anake nei e wheako e mahi werohanga intraocular.

I muri i whakaurua te taputapu, i te kore te mea e manakohia ana ki te tiki i muri i te wira o te motokā, me te mahi i te mahi e pā ana ki nga tikanga, me te katoa hoki o te mea e whakawhanake raruraru ataata rangitahi.

Me anake kia penapena "Avastin" (tohua te kaiwhakanao i roto i te tohutohu) i roto i te pouaka whakamātao, i roto i tetahi take e kore me whakatotoka reira. operehia te reira i te whakahaunga anake.

Me pēhea te ki te taunekeneke "Avastin" ki ētahi atu taero?

Drug "Avastin" he hotokore ki rongoā terehuka. Hoki, kia whakapiki ake i te raau taero i te mōrea o tauhohe kino ina tangohia i roto i te taha ki te taua tikanga:

• "Malate Sunitinib" - kia puta whakawhanake anemia hemolytic microangiopathic;
• konukawata me taxanes - pōauautanga taea o pathologies hopuhopu, neutropenia nui, nui ake te mōrea o te mate;
• "Panitumumab" me "Cetuximab" - faarahi te pānga paitini o taero me arata'i ki te mate.

"Avastin" i roto i te Ophthalmology

Nuinga tata, ka puta te kōrero i roto i te press e ki te tarukino "Avastin" whakamahia e ophthalmologists hamani mate o te kanohi, me te homai hua rawa pai. Ko he reira? Aha tenei ta e pā ana ki te kaiwhakanao? He tenei taputapu ka taea e koe ki te mutu kore anake te tupu o te pukupuku, engari ano ki te ora ai nga mate o te kite?

Ae, i roto i te meka i reira he kōrero e kua rongo etahi tūroro e pā ana ki te painga o te tarukino ki te kanohi, ka maia ki te hanga i te pere "Avastin" i roto i te tangiwai, engari kino nga hua i. Te raau e kore ratou i kawea e tetahi whakaora, i runga i te anga ke, arahina ki te meka e te iwi he matapo tika. Kua toutou fakamamafa'i "Roche" kamupene e kore e taea te whakamahi "Avastin" i roto i te Ophthalmology, he rerekē tona whakaaro.

tikanga te tarukino te ki te whakaiti i te kaha o te tupu o te oko toto e atawhaitia te mate pukupuku, te kupu i te whakaiti i roto i te whanaketanga puku kaha. Ko te aha i mua i te tīmata therapy, me te whakarongo tūtohutanga unsubstantiated pai ki te kōrero i te tākuta.

"Avastin": ritenga

Ko ahakoa i reira ko te whakakapinga, e pai ai i roto i tona hanganga, ko te taonga taketake taua, e kore e hanga i te reira ratou "Avastin". Analogs o te huarahi o te mahi ko, a hoatu ano e ratou hua pai i roto i tērā ki raro, te tupu o oko toto, me te whanaketanga o te pukupuku matepukupuku. Ko ētahi o ēnei:

• "Arzerru".
• "Campath".
• "Rituximab".
• "MabThera" et al.

Engari me mahara reira e kua ki te whiriwhiri orotahi te tākuta.

"Avastin": whakautu o tūroro me rata

"Avastin" (whakapumautia ako ā-te) he anake te tarukino e kei roto i tona bevacizumab hanganga, e tauturu te reira ki te pōturi te tipu o oko toto kai i te puku, reira tērā iho te haereraa mate. Te nuinga o nga rata e kitea nga akiaki o te mate i roto i te manawanui ngā, mea ratou e i roto i o werohanga i te tokorua e kitea tērā tupu puku, te mea matua - te tika ki te tango i te tarukino, me te kore e ngā reira ki taero e i roto i ngā e taea meinga kino nui ki te manawanui.

Whakarāpopoto, ka taea e tatou te mea mo te tino e "Avastin" (kaihanga - F. Hoffmann-La Roche) - he ataahua, e tauturu roa te ora o te tūroro ki te pukupuku matepukupuku. Ko e te tika anake ana ki te faaohipa i te reira i raro i te te tirotiro tino o te tākuta, te kore i taea e te mau hopearaa e tina heke, me te mutunga kanohi.