He aha "Lyrics" papa? Ko te whakamahi o te utu

Medicine "lyrics" (papa), te utu o te mea i 700 ki te 4000 moni, -. Makona pai-mohiotia tarukino. taonga hohe - pregabalin - tairitenga o te gamma-aminobutyric (o Kapa) waikawa (o Kapa). Ka I muri i roto i te tuhinga kia hoatu tuhipoka ki rongoā. Kia kitea tatou i roto i te mea pire "Lyrics" te whakamahi i tūroro.

tikanga o te mahi

Pregabalin whakaaturia tona miramira i te maimoatanga o te neuropathy mate huka, me te roro postherpetic, hoki nei pire "lyrics" whakaritea auau ki runga ki te 13 wiki ki te auau horomanga rā 2 nga wa, me te ake ki te 8 wiki, 3 ngā wā i te ra. Ki te whakamārama o te whanaketanga o te tikanga tohu nga pānga taha ano. E pā ana ki te fibromyalgia ko mārama whakaiti kitea i roto i ngā tohu mamae Point i te tango i te pota tarukino o 300-600 mg ia ra. Ka taea te whakaritea inenga Daily o 450 mg me 600 mg mo pai, engari kei te iti te pai noatia te whakamutunga. te whakaiti i te tarukino te pakeke o haurangi hunga haurangi, e papa "lyrics" tūtohu te akoranga o te 12 wiki, 2 ranei 3 ngā wā ia ra. I roto i te fariiraa puta te tauira ano o ngā pānga taha me te whai huatanga o te tarukino i tenei horopeta. tīmata ärai auau ki te whakaiti kē i roto i te wiki tuatahi o te maimoatanga. Tohutanga o te whakararuraru, manukanuka te whakatakiruatanga o whakaatu he hehema ki te whakaiti i roto i te ra tuatahi e whitu o te maimoatanga. I muri e waru wiki 52% o te tūroro tarukino te fariiraa pregabalin me 38% o tūroro te fariiraa i placebo, whakakitea te whakaiti 50 ōrau i roto i ngā tohu o te tauine Kirikiriroa (HAM-A).

Pharmacokinetics

Ko te medicament "lyrics" (papa) - fakapapau'i tenei Kaiwhakamahi - i roto i te pota tūtohutia rā ki pharmacokinetic taha linearity āhuatanga, iti (<20%) rerekētanga interindividual. Ka taea te tohu tono toutou o nga pharmacokinetics o te raau taero i runga i te pūtake o te kōwae o ngā raraunga inenga. Na reira aroturuki auau i te kukū o te whakauru kaha kore te mea e tika ana. tawhā Pharmacokinetic o te tarukino "Lyrics" i roto i tūao hauora, tūroro ki haurangi e farii i therapy antiepileptic, me te fariiraa i te tarukino mō te pehi syndromes mamae e rite.

Absorption me te whakakorenga

I muri tango i runga i te pregabalin puku kau te riro rawa hohoro. Kotahi haora i muri, tutuki te wē Cmax rite ka tono mo te wa tuatahi, a ki korerotia. I runga i te whakamārama o te bioavailability waha pregabalin ko i ≥90%, me te he motuhake o te horopeta. tutuki taurite te ka mau toutou i roto i te wā o te 24-48 haora. Ki te tono te tarukino te i muri i te kai, kia heke te Cmax e 25-30%, me te whakapiki ake i tona wa paetae ki 2.5 haora. Heoi, kahore pānga hauora nui i runga i te absorption o te tarukino kihai i whai kai. Fele te raau excreted e nga whatukuhu tonu. T1 / 2 toharite o 6.3 haora.

Pharmacokinetics i roto i ngā take motuhake

Ki te taupatupatu koe mahi tākihi, he mea e tika ana ki te tango i ki pūkete te taa o pregabalin whakawātea, he reira tika hautanga ki te creatinine paranga. Fele te raau excreted e nga whatukuhu, koia ko reira tika i roto i te take o te ofatiraa o ratou mahi ki te whakaiti i te horopeta. I tua atu i nga whatukuhu, e taea te tōtika nekehia te medicament i te wē i te tātari toto (4-haora wātū tātari toto homai 50% hekenga i roto i te kukū tarukino i roto i te wē) me ka atu minaminatia horopeta whakarite tarukino. He ako motuhake o te pharmacokinetics o āpiha "Lyrics" i roto i te tūroro ki te mahi ate waimaero kihai i whakahaere.

Pregabalin metabolized tata kore kitea, e whakaaturia tahi me te mimi i roto i te puka tonu, heoi e kore e mahi ate waimaero tino pā te kukū o te tarukino i roto i te wē. A, no te mea kua hoatu te tarukino ki te tūroro i runga i te 65 tau o te tau, me mau e koe i roto i te ngakau e ki tau whangai Pregabalin whakawātea ki te whakaiti. Ki te heke haere te tangata ruhiruhia o mahi tākihi, he mea whakaiti tika i roto i te rongoā i whakaritea horopeta.

inenga

Ko te nui ia rā o te faaineineraa tautuhia i roto i te mg 150-600 ia ra. kawea Urunga te i roto i rua e toru ranei nga wa, ahakoa o te kai. E taunaki ana te medicament "lyrics" (papa) ā-ako tango ki te mamae neuropathic i 150 mg ia ra. Ki te kia te nui haere te pānga tutuki me tolerability pai kotahi wiki horopeta rā ki te 300 mg (tautapa "lyrics 300" papa). Ki te tika, kia whakahaerea ai te horopeta mōrahi o 600 mg ia ra kotahi wiki i muri mai. Waihoki tatau horopeta i te maimoatanga o te haurangi. Ka rite ki i whakahuatia i runga ake, i te reira tarukino tūtohutia hoki te maimoatanga o te fibromyalgia, e papa "lyrics" e faaterehia i roto i te horopeta o 75 mg ia ra i roto i te rua werohanga. I te whakanui ake i te horopeta ki te 300 mg pā te pānga tutuki me tolerability. Ki te kahore he pānga pai, te whakanui ake i te horopeta ki te 450 mg, a ki te hiahiatia - kotahi wiki ki te 600 mg. Hamani te whakararuraru, manukanuka whānui timata ki te horopeta o 150 mg. Ano he wiki, te mātakitaki i te pānga tutuki me tolerability, nui haere te horopeta rā ki te 450 mg, a i muri i te 7 nga ra - ki runga ki te 600 mg (ki te tika).

tango o te tarukino

Ki te tika, tūtohutia maimoatanga korenga atu te ki te rave i te reira i te iti rawa hoki te wiki he whakaiti āta i roto i te horopeta. Tūroro e kua waimaero tākihi mahi, kawea atu kōwhiringa takitahi o pota. I roto i te kaupapa o ngā pānga kōaro i roto i te tūroro te whiwhi tikanga "Lyrics" pire-ritenga kōwhiria e te tohunga. I roto i te tikanga tino noa ki pānga rite ai kia whakahuatia taero "Mydocalm" "Apizartron" "Sedavit" "Ambene".

iteraa papû

Kei te tūtohutia rongoā mo te whakakorenga o te mamae neuropathic, rite therapy adjunctive mō hukihuki wāhanga o te haurangi, e kua haere tahi ranei kihai haere tahi i te whakatau tuarua. tohua Founga hoki manukanuka whakararuraru, te whakatakiruatanga o te natura, me te fibromyalgia.

contraindications

E kore raraunga i runga i te whakamahi o te raau taero i roto i ngā tamariki me ngā taiohi ki runga ki te 17 tau urutomo. I roto i te hononga ki tenei rongoā whakaritea te anake ki ngā pakeke. Contraindications ngā mate tuku rite galactose ātete, lactase hē, me te malabsorption o te kūhuka / galactose. E kore te te taputapu tohua mō te hypersensitivity. Ki te mau tonu te whakamahi tupato o te tarukino i roto i te tūroro ki te tākihi me te ngakau kore.

pānga taha

E ai ki te wheako o te tono haumanu o te medicament, i roto i te momoe tohua me te whanoke rite nunu'a houhou. Ēnei ari ahu ki te puta i roto i te tohu āhua ngawari ranei. I roto i hua atu pānga taha i roto i te korenga atu o te maimoatanga tarukino, kia tuhia te reira asthenia, whakama, kite te peroo, incoordination, ataxia, edema piringa. i roto i te pānga kino hoki tuhia ānini, mate o mahara, hukihuki, pupuhi o te arero, korere, whakapairuaki, keratitis. Varavara i kiri oranga, me te tauhohe angioneurotic. He pupuri mimi, edema pūkahukahu me te gynecomastia. ka karanga i roto i te tahi atu ngā pānga taha te rohirohi.