Nui haere ALT. He aha ki te mahi?

alanine aminotransferase (ALT) whākōkī i roto i roto i te ate whakamahia hei tohu ki te kitea disorders o ona mahi. He aha e te meka, ki te nui haere ngā taumata ALT?

I roto i te whākōkī maha e he tohu o disorders hepatocellular, te whai hua tino me e tika ana he aminotransferase alanine (ALT) me aspartate aminotransferase (AST). Na roto i whakatere ratou tauhohenga whakawhiti i roto i te gamma-kama alanine ropu ketoglutarate me ngā rōpū aspartate. Ka rite ki te hua o tenei tukanga whakaputaina pyruvic me te waikawa oxaloacetic.

Na ALT me AST - pūtau whākōkī whatukuhu, ate, ngakau. Heoi, aminotransferase alanine, te nuinga kei roto i te ate, me ko te taketake tino o tona tohu, me aspartate aminotransferase -. Ka rite ki te wahi o maha (i tua atu i te hunga whakarārangitia i runga ake) o whēkau me te kopa, tae atu uaua kōhiwi, roro, me ētahi atu tenei he aha he iti noa te AST paru matua hei tohu o te ate mahi, a e te reira wahi i roto i te waikawa amino pākia.

Ki te kahore he whakangaromanga o ngā pūtau ate, ngakau, tākihi, alanine aminotransferase (ALT) i roto i te wairere toto. Hua o te whākōkī pūtau i roto i te hanganga toto tohu mate moe. A, no te whakaatu rangahau e ngā taumata ALT tiketike, kia whakawhanake i mate rawa nui i roto i te toto, pērā i:

- cirrhosis,

- kakā viral,

- myocarditis,

- ate mate pukupuku,

- kore ngakau,

- te whakaeke ngakau.

Na te aminotransferase hua aspartate i roto i te toto e taea arahi ki

- whakaeke ngakau,

- ate mate pukupuku,

- Duchenne ,

- pancreatitis,

- paroxysmal myoglobinuria,

- kakā,

- dermatomyositis,

- kore ngakau.

Ki te, Heoi, nui haere te auau whānui o te AST me ALT, i reira kia kia:

- whānui necrosis ate,

- toksinogennye ate whara,

- nui kakā viral,

- tiango roa-iaia.

Tata whakaatu mate katoa o rangahau toto tangata e nui haere te auau me AST, me ALT, ko e, ko tata te taua te taumata o whākōkī e rua i roto i enei take, me te whakaatu i te aroaro o te māuiuitanga. Ko reira te mea ano tetahi atu rerekētanga. Ki te nui haere ngā taumata ALT ki te whānuitanga nui atu aminotransferase aspartate, e tohu te wā heki o te kakā B mate. Ki te te ACAT toto ake, reira atu maha ki raruraru ngakau.

I roto i te tangata hauora kia te tirotiro o enei whākōkī pūtau i te taumata:

- i roto i te tangata ki runga ki te 41 wae ia rita (U / L);

- i roto i nga wahine ki runga ki te 31 wae ia rita (U / L).

Ki te tautuhi i te taumata o enei whākōkī, te pūmua pākia, tango matū toto. Täkupu mō te ALT reira e 28-190 nmol / (c l) 0.1, 68 mmol / (mL hr) me mo te ACAT ranei - 28-25 nmol / (c l) 0,1- ranei, 45 pmol / (mL hr). Kei roto i wā e rua i homai tenei ture e mo te tikanga o Reitman-Garden (tikanga colorimetric o rangahau).

Ko te tikanga, whakamātautau toto alanine aminotransferase whakahaere ki te ako e pā ana ki te āhua o te ate, me aspartate aminotransferase - ki te kite i te āhua o te myocardium (uaua ngakau). Ki te whakaatu i te tātari ratou toto teitei, te auraa e te tukanga o te whakangaromanga, me te mate pūtau puta i roto i enei whekau. Na, ki te mea nui AST tona taumata i roto i te toto i roto i te 2-20 wa, na ko reira taea te whanaketanga o te infarction myocardial. Ki te nui haere ngā taumata ALT, i reira te mea he tukanga pathological i roto i te ate.

I raro i tohu iti o te toto alanine aminotransferase me aspartate tohunga aminotransferase mohio e kore o pyridoxine (huaora B6) o te tinana. Ko te tikanga tupu tenei te wā hapūtanga, ki tātari toto auau, me te mate täkihi.

Kia aroha mai, i te serum toto o te tangata hauora ko enei whākōkī he unknown, na te hé me ratou tikanga o te whakawātea (tere o te tere o te maimoatanga wē, atu bioliquid me te kopa o tetahi matū no o ratou tohatoha anō, biotransformation, whakakorenga i te tinana).