Paturopi ki DNA rua-paea - rawa tikanga me te wetemunatanga

Anti-dsDNA (antiDNK) ranei paturopi DNA rua-paea he rōpū heterogeneous o paturopi ki DNA rua-helical, me te i roto i tohu taiwhanga o whakamatea (pūnahanaha erythematosus lupus).

E huaina Autoantibodies ki DNA, e kua tū i roto i te karihi paturopi ki DNA rua-paea. Kua kore i kitea te take tangohia i roto i te toto.

He aha te mea he antibody?

Ko te pūnaha ārai mate te tangata ki te whakaputa i paturopi, pera-ka karanga pūmua motuhake e whawhai pirinoa rerekē, wheori, harore, huakita, arā ki ngā āhuatanga ke i runga i te taumata ira. Ko te mahi ngā tetahi antibody ki te whakangaro i rauemi ke, me te e kore e pa ki te pūtau taketake, huaina whaiaro kātakí-tikanga.

He take ka whakahaua te urupare ārai kei ki ona ake kopa me ngā pūtau, e kore e ke. Na reira ko te whanaketanga o te mate autoimmune, me paturopi hua ki ona ake pūtau me ratou wāhanga, ka karanga tohunga autoimmune.

Ki te te hui o te "kore" nui o te mate, nui haere taumata o autoantibodies, i te mea tino rawaka mō te atamira i te tātaritanga manawanui.

Paturopi ki DNA rua-paea - e kore te mea kotahi, engari he whānui katoa o ratou, e ko te karihi DNA ūnga pūtau antibody.

Ko tino tairongo mo te tātaritanga o patua antibody whakamātautau, arā, ka taea e te hua pai kōrero e pā ana ki te haamauraa o te tātaritanga. I roto i te 70-80% o te wā, kua tāutuhia tūroro ïa tenei tātaritanga. Heoi, e tika ana ki te tūtohutanga iti o te rangahau titau tiaki nui ka pānui hua whakamātautau, me te mea he kino te hua, e kore ko reira te meka e kore e te manawanui i whakamatea.

maha whakaritea ēnei assays rheumatologist. Ko taea te tuhituhi i te reira arata'iraa, me te kaihaumanu, me nephrology, me Dermatology. ka whakawhirinaki i runga i ki te mea ngā tohunga te manawanui te tīmatanga mea katoa. taiwhanga immunological - ko te wahi, te wahi whakahaere ia rangahau i runga i te antibody tenei. e kore te mea e tika ana te faaineineraa Special mō te tātari.

Whakamatea - pūnaha Lupus Erythematosus

Whakamatea ko te mate nui autoimmune e pā pūnaha okana maha (pūnaha o te roro, kiri, whatukuhu, hononga, oko toto, me te ngakau). E kore te te aroaro tukutahi o ngā tohu i roto i te tinana katoa e hiahiatia ana. He Faaiteraa o lupus rawa rerekē: ka taea e te tangata kotahi tohu kiri, te tahi atu, hei tauira - tākihi.

e tauturu i te paturopi ki taketake DNA rua-paea tautuhi i te mate.

āhuatanga Risk mō erythematosus lupus pūnahanaha

• huringa hormonal (whanau, hapūtanga, paheke), i whakaarahia prolactin me estrogen, e whakamārama te auau teitei o 90% o mate i roto i nga wahine.
• He predisposition ki te taumata iranga, e haapapu te aroaro o whanaunga o tūroro mate i whakamatea taumata iti o etahi antigens o pūnaha hľa me autoantibodies.
• Drugs - "methyldopa", "Procainamide," "Hydralazine".
• pāngia e mate viral nga tukanga autoimmune.
• radiation Solar (meinga hihi katinga pūtau kiri ki apoptosis DNA whanau, a riro te reira kitea ki te pūnaha ārai mate).

Tātaritanga o paturopi he tino mōhiohio ki te DNA rua-paea.

tohutanga o whakamatea

kia huaina ai ngā āhuatanga noa o faaiteraa kōpuku tetere taikiri, ngoikore, me te rohirohi, kirika, mate taimaha, te mamae tahi, me te uaua.

• Lupus pauku ranei täkihi (tākihi mahi a heke i reira ko te topu- o tohu taiwhanga).
• Rumati me arthralgia, meinga mumura me te tetahi raru i roto i nga hononga o nga ringa, ringa, e whakaatu ana i te whakaiti X-ray i roto i te mātotoru wheua huri noa te tahi (osteoporosis periarticular), Heoi, e kore e erosions.
• Serositis, e ko mumura o te membrane serous o te ngakau me te pūkahukahu (kiripūkahu, pericarditis).
• Photosensitivity, meinga ähua o tohu i muri i te rongo ki te ra.
• Hikaka, tae atu i runga i te mata, te hunga ponana pūrerehua. E kitea e tika ana paturopi ki DNA rua-paea.

• syndrome nephritic - 45-65%.
• hematuria mōkitokito - te aroaro o 80% o ngā pūtau toto whero i roto i te parataiao mimi.
• e pā ana Proteinuria i te mate o te pūmua i roto i te mimi i roto i te rōrahi nui ake i te 0.5 g / s, i.e. 100%.
• Tino onge i roto i te mimi nui nui o leukocytes (pyuria), rawa i roto i te ngaro o te mate mimi.

• whitiki miro-rite tuaroa i hanga ano hoki putapu te papilla whatu.
• Ko te aroaro o te pneumonitis whakapeka lupus, kino pūkahukahu, maremare me te feohi kirika ki kookuhutanga kauae ingoingo.
• Faaiteraa o ngā āhuatanga neuropsychiatric mai i whārua me whakamutu ki paroxysms epileptiform, āhotea me hauā ataata.

A, no te tāutu i te manawanui ki te paturopi whakamatea ki te DNA rua-paea hiahiatia te roto 1-3-6-12 marama mana toutou. Tei te reira i runga i te pakeke o te mate. I roto i enei tūroro faarahi te mōrea o te kino tākihi, no te mea antiDNK complexes ki complexes ārai arahi ki kino tākihi.

Analysis antiDNK

Ko te tika tenei tātari:

• Ki te matapae angitu maimoatanga.
• A, no te te parenga ko reira he mate autoimmune nahanaha.
• A, no te te hua o Ena antibody rangahau paturopi pai antinuclear.
• A, no te e kitea tohu o whakamatea.
• A, no te te aroaro whakapae o te mate pūnahanaha, ngā patua.
• Hoki te tātaritanga pārōnaki o syndrome articular.
• A, no te te hua whakamātautau he pai antibody antinuclear.
• Hei matapae i te whanaketanga o te kino tākihi.
• Hei whakahaere i te rere o te moni pakeke.

Eaha te tupu ki te tangata, ka whakaara ia paturopi ki DNA rua-paea?

Tohutanga mō te whakatau antiDNK

• Nui haere te pāmahana tinana, taikiri, heke taimaha, puta rohirohi.
• Rumati, mumura o nga hononga, whakakitea puku, mamae, kirika i roto i tenei rohe, reddening o te whakararuraru, kiri, me te nekeneke.
• A, no te nga tohu hinengaro, me te neurological mohiotia.
• A, no te kiripūkahu pericarditis o te take unknown ranei.
• A, no te syndrome o Raynaud, arā, he huringa wā i roto i te tae o maihao, me waewae (whero, koma, puru), he takahi o ratou tūtohutanga me te mamae.
• Tākihi mate he he hua ārai Genesis huringa mimi ranei tātari (hematuria, proteinuria).
• A, no te tohu kiri - thickening o te kiri, rashes, rawa i muri i pāinaina.
• anemia Hemolytic, whakangaromanga o ngā pūtau toto whero i ngā taumata teitei o te bilirubin i roto i te mimi me te toto.
• A, no te neutropenia, heke neutrophil tātai leukocyte.
• A, no te thrombocytopenia, iti i roto i te maha o platelets i roto i te toto.

Paturopi ki DNA rua-paea: noa

Tikanga, kia kia tōraro te hua tātari, me te kukū o te 0-25 Iu / ml.

Ki te he pai te hua, ka taea e tatou te mea: cirrhosis biliary tuatahi; whakamatea; mononucleosis hopuhopu; tōtika maimoatanga (whakamatea i roto i te murunga); ma'i B kakā me C; syndrome o Sjögren; whakauru mate kiko tūhonohono.

DNA Double-paea me paturopi (IgG me IgM immunoglobulins) hanga he matatini ārai. meinga ana e ia te tahi mau tohu āhuatanga o whakamatea.

Ki te he kino te hua, kōrero e pā ana ki lupus tarukino ngaro o te SCR ranei.

E pā te hua o te tātari?

• reiti High antiDNK e pā ana ki lupus pauku, exacerbation o mate kore o te mana i runga i te mate ranei.
• reiti iti antiDNK e pā ana ki te whai huatanga o te therapy me te paetae o te atamira o te mate murunga.
• AntiDNK whakamatea ko te tohu motuhake, engari kia puta ano hoki i roto i te tahi atu mate (autoimmune, kakā C me te B).
• Ki te antiDNK kahore, e kore e tenei aukati i te tātaritanga o whakamatea.
• e kore te rapunga antiDNK manawanui, kahore tetahi tohumate me ētahi atu paearu o te mate tukinotia i roto i manakohia o te whakatakoto i te tātaritanga o whakamatea.

Pānui nui

Ko te whakamātautau toto mo paturopi ki DNA rua-paea puritia i roto i te taha ki te akoranga e whai ake nei:

• beta-2-microglobulin;
• tātari toto whānui;
• paturopi antitsentromernymi;
• tātari mimi whānui;
• paturopi antigistonovymi;
  

• whakamātautau ate mahi (phosphatase kawakore, bilirubin, GGT, AST, ALT);
• Revmoproby (Aso, te pūmua C-urupare, tauwehe rheumatoid, ngeniwhero auau parataiao);
• tsitrullinovomu peptide antibody (anti-CCP);
• paturopi Antinuclear (Ana). Ko nga autoantibodies tino pai-ako me ki tauwehe rheumatoid. I kitea te reira i roto i 1957, me i te wa ano, kua kï kairangahau hononga ki whakamatea. Ko te kupu paturopi ki DNA rua-paea whakatairangatia ana;

• anti-SSB me anti-PITIH paturopi;

• anti-SCL-70 paturopi;

• paturopi anti-nRNP;

• paturopi anti-Sm;
• paturopi anti-sp100.

E rua ngā meka e pā ana ki antiDNK

I tua atu, puta antiDNK i te toto e tika ana ki te take e whai ake nei:

• myeloma maha;
• Patua tātaritanga paearu o te mea ki te whiwhi i te putanga pai o te rangahau;
• mate pravovirusnoy;
• tarukino inutsirovannoy whakamatea;
• HIV;
• syndrome o Sjögren;
  
• cytomegalovirus mate;
• syndrome Sharp (whakauru mate kiko tūhonohono);
• mononucleosis hopuhopu;
• kaikōiwi;
• cirrhosis biliary tuatahi;
• sclerosis pūnahanaha;
• kakā C huaketo;
• B. kakā viral

Na reira, tango tino maha toto hoki paturopi ki DNA rua-paea.