Pemphigoid Bullous: tohumate, maimoatanga, me ngā whakaahua

pemphigoid Bullous - he mate kiri āhua noa e rite te faaiteraa waho o pemphigus. Te mate puta i roto i te puka ma'i, me i te ngaro o te tātaritanga arä, me te maimoatanga e taea arahi ki hopearaa kino. Na te aha ai te whanaketanga o tenei mate? He aha e nga tohu faaite te reira iho? He aha e nga tikanga hoki kua te maimoatanga o te rongoā hou ki te whakahere? Pahonoraa ki enei pātai e o te pānga ki maha kaipānui.

He aha te mea he mate?

pemphigoid Bullous i roto i te rongoā hou mohiotia e ingoa maha - e mate o Lever, me pemphigus taipāpā, dermatitis herpetiformis me taipāpā. Ko te ma'i mate autoimmune, haere tahi nei i te ahua o te hunga ponana kiri o te namunamu nui (tohu waho ētahi wā rite pemphigus pono).

E tano ia tapao e te nuinga rawa o tūroro ki tenei tātaritanga - ko reira te iwi koroheke 65 tau, me te pakeke. Noatia, mohiotia rongoa okotahi, kia rite ki te tahi mau taime kitea te mate i roto i ngā tamariki, me ngā tūroro waenganui-koroheke. huru no te ma'i e te akoranga Koló, engari ka taea e ētahi wā arahi i te reira ki pōauautanga. kīnakinaki te pikitia haumanu o te pai whanaunga ki wā o te exacerbation. O te akoranga, mo te iwi maha, te pātai o te moni ko te meka e ko te pemphigoid bullous. Tohu me te maimoatanga o te mate, ona take - kia atu āta pānui i tenei mōhiohio.

Ētahi mate rite

E tano ia tapao e te pemphigoid bullous he wahi o te rōpū o pera-ka karanga dermatosis whēwhē. E kitea ana ēnei mate i te pemphigus pono, mai i kore te reira tahi e te acantholysis. rōpū pāpaka kiri ngā maha ngā mate, te pikitia haumanu i te mea tino rite:

• neakantoliticheskaya pemphigus Koló i ai mate pānga anake te mucosa-waha, kahore meinga rashes i ētahi atu pae. Kei te hoki huru no te mate e te akoranga Koló. E te ara, i whakaahuatia tuatahi reira i roto i 1959.
• Mātānawe pemphigoid - rawa te mate kino e pā te membrane mucous o te kanohi, me te kirikamo, meinga ana e ia ki te atrophy. He taea rashes runga i te tinana, engari puta ngā pinepine. Ko te rōpū mōrea matua - wahine 50 tau o tau, ahakoa i ētahi wā tuhia te mate te roto tūroro tane.

Ko te take, me te pathogenesis o pemphigoid bullous

Kia aroha mai, Kei te tonu e kore i matau tino te huarahi o te takanga o tenei mate. Heoi, i taea e ki te rapu i he autoimmune i te natura te mate pūtaiao. Hoki tetahi take ranei tetahi reira he rahunga i te mahi o te pūnaha ārai mate, hua i roto i te he paturopi hua e kore whawhai ke anake, engari ano hoki o te tinana ngā pūtau ake.

E wātea ana Taunakitanga o tenei ariā. I roto i te serum o te rangahau manawanui, me te i roto i te wai i tangohia i te mirumiru, kua kitea he paturopi motuhake ki te tūkino i te membrane basal o nga kopa kiri me kiriuhi mucous. Hoki, i kitea ai e whakawhanake te kaha atu te mate, te teitei te titer o enei paturopi.

Kei te whakapono te reira e kua meinga mate autoimmune e iranga. Heoi e hiahia ana koe ki te me'a e taea te whakahohe i te mate. Ka taea e kia tenei:

• Vaccination ki etahi mate;
• kino ritenga kiri nui ranei;
• te rongo ki te radiation hihi katinga (pāinaina roa, tūkino solarium, aha ...);
• weranga waiariki ki te kiri;
• whakamahi auau o etahi rongoā, pērā i "Furosemide", "captopril", "phenacetin", "amoxicillin" me etahi atu;
• I te tahi taime whakahohe te mate te i muri i te wahi o te therapy iraruke manawanui;
• pato'iraa transplant tākihi, korerotia okana transplantation.

Bullous pemphigoid: whakaahua me tohu

O te akoranga, te tuatahi o katoa he mea nui ki te waia koe ki nga tohu, no te mea ka utu i te wawe te manawanui whakarongo ki te oraraa o maumaui me rapu tohutohu hauora, te māmā te tukanga maimoatanga tango wahi. Mātauranga i runga i te kiri hūnga vesicular kaha - te āhuatanga matua o nei tahi e pemphigoid bullous (whakaatu Photo te titiro o te hunga ponana). Nuinga o ngā wā ka pā te kiri o nga wahi, me te kātua. kia hikaka te puta i roto i te mara o Whētuia tūturu nui i runga i te mata, me te tumuaki, engari tupu te reira varavara.

Ko te āhuatanga matua o te hū - vesicles me opupu ki te potae takoki. Roto kitea e ratou he wai, te tikanga mārama, engari i ētahi wā kia kite koutou toto. E mea pinepine, te kiri a tawhio noa te mirumiru whero.

Ko te wā o "te ora" o ngā o te torutoru nga ra. I muri i taua, ratou māhorahora whakatuwheratia. I te pae o pāpaka i hanga wāhi horo me mariao iti. e kore e kirinuku i runga i te mata i hanga kia rite ki ngā wāhi erosive hohoro epiteliziruyutsya.

timata nga wāhanga tuatahi o te mate i roto i te 20% o tūroro ki te ahua o mirumiru i runga i te mucosa-waha, a ka tomo te hunga ponana kiri. Opupu i runga i nga kiriuhi mucous o te ihu, korokoro, kikokiko, puta rawa uaua kanohi.

Tūroro amuamu o minamina, a i muri i te whakatuwheratanga i te mirumiru me etahi tetahi raru. Pea te hua i roto i te pāmahana, ahakoa he onge tenei. I roto i te tūroro kaumātua, te tinana mauriora e te e relapses auau, kei te kitea hoki he hekenga i roto i te hiahia, mate taimaha, ngoikore ahu whakamua.

Histogenesis, histopathology me te patomorfologija

Ko te tino ngā māuiuitanga bullous pemphigoid. Tuatahi tukanga cytoplasmic i waenganui i ngā pūtau basal i hanga maha vacuoles. Āta e hanumi huihui enei ngā ki te hanga i ngā hanganga nui. Te taha ki tenei, i reira ko te koi me te edema o nga kopa ākiri.

Taira tōngāmimi - he epidermal kiko. Pūtau ona totoro, otiia e kore e nga piriti i waenganui ia ratou pakaru. Ko te memeha äta atu o nga pūtau epidermal Ka rite ki te mate. I te wa ano, kei te tata kiko epidermal hou ki tapa mirumiru, te hopu i tona raro - ko te kupu vesicles nuku roto o nga kiriwaho me ētahi wā i roto i te apa podrogovoy.

Roto te mirumiru i reira ko te inu e kei lymphocytes ki te hawhekaihe o neutrophils. He whenu o pūtōtepe, nga rāpoi pūmua me etahi atu pūhui.

Ki te whakaaro tatou te histogenesis o pemphigoid bullous, tuatahi ko reira utu te haamana'oraa e he autoimmune te mate. I roto i te ako o te kopa i te irahiko karu taea te tuhia e kei pera-ka karanga antigens BPAg1, e kua tukua i roto i te whakautu ārai i roto i te paparanga basal, ara i whakatika keratinocytes poludesmosom. Ko tētahi atu antigen - BPAg2 - kei hoki i roto i te poludesmosom rohe. Kei te whakapono te reira e te hanga e te reira na roto i te momo collagen XII.

Ano i roto i te rangahau i te reira kua kitea e macrophages me eosinophils i roto i tenei mate te tīmatanga kohikohi i roto i te membrane basal, a ka heke i roto i taua mea, ka timata ki te whakaemi i roto i te tōngāmimi, me te i waenganui i nga pūtau basal. Ano, i reira te mea he degranulation nui o ngā pūtau rewa.

Histologically, kitea te mate e, no te exfoliation o nga kiriwaho i te kiri, a i waenganui i hanga e te namunamu subepidermal. whakawhānui hoki oko i roto i te kopa kiri, i reira te huamo o te paparanga roto (endothelium).

tikanga Modern o tātaritanga

Ka rite ki te tikanga, i reira he kahore fifi ki te tātaritanga o taua mate rite pemphigoid bullous: he tino motuhake nga tohu, a reira kia whakapae tō tākuta te mate kua i roto i te tirohanga paerewa. I te kiri o te manawanui e hanga e mirumiru kikī, ka puta te tukanga o te epithelialization o erosions tere.

Peel whakamātautau kiriwaho kino. I tua atu, kawea te taiepa i roto i o te tirotiro ā-o te mirumiru ki te whakamātautau histological atu. I roto i taiwhanga taea te kitea whakamātautau i roto i te vacuoles wai āhuatanga histiocytic, eosinophils me lymphocytes.

I te tahi atu te ringa, he ētahi wā mahi wehe ki fifi te tātaritanga pārōnaki, rite te pikitia haumanu ko paku haamana'oraa o te tahi atu mate kiri, tae atu erythema multiforme exudative, pono, me te pemphigus herpetiformis dermatitis Dühring.

He aha te maimoatanga whakaaro te ki kia whai hua?

He aha te mea i kitea e koe i pemphigoid bullous? Treatment i roto i tenei take titau te matatini. Ano, ko te kōwhiringa o ngā mahi hākinakina me te rongoā tei runga i ngā āhuatanga maha, tae atu i te pakeke o te mate, te tau, me te hauora whānui o te manawanui, aroaro o comorbidities. I roto i tetahi take, kia hanga ai te talena maimoatanga anake i te rata haere.

Ko te pūtake o te therapy - pūtaiaki drugs anti-inflammatory kei roto steroids. Nuinga o ngā wā e whakamahia ana mō tenei whakaaro "Prednisolone". whakahaere te tarukino te pâmuhia me te āta heke te inenga rite te ngaro o ngā tohu.

Ano, he pānga pai, ko te cytostatics homai me āpiha immunosuppressive e āwhina i ki haerenga i te mahi o te pūnaha ārai mate. Tino maha, tūroro whakaritea taero pērā i "Cyclosporin A", "Cyclophosphamide", "Azathioprine".

O te akoranga, te wāhi nui ko te maimoatanga o pāpaka, erosions me mariao i runga i te kiri. He mea tika ki te pupuri i ma te kiri. Tūroro whakahaere rongoā ki ngā waikano aniline (hei tauira, "Furkotsin") e mahi rite antiseptics ranei maroke i te kiri. I roto i te wā atu kino rapua e hoki hinu ki steroids.

Maimoatanga ki rongoā iwi

pemphigoid Bullous, ranei mate Lever - he māuiuitanga e titau te mātau, maimoatanga tohu. Ko te whakamahi o ngā rongoā kāinga taea, engari anake ki te whakaaetanga o te tohunga. I mua ka taea e koe te whakamahi i tetahi tikanga kia kōrero koe ki tō tākuta. I roto i te iwi rongoā e whakamahia ana te whānuitanga o drugs rerekē.

• Kei te whakapono te reira e te āhua pai o te hauora o te manawanui pā te tincture o Eleutherococcus. Tangohia kia waiho he rua ra, 30 pata.
• Hoki waho tukatuka wai whakamahi hikaka te i te rau o te aroe, e āwhina ki te atawhai minamina me tetahi raru, ārai te whanaketanga o te mumura, whakatere houtanga. Ko te wai e hiahia ana koe ki te whakamakuku i te tipare, ka tono ai ki te wāhi kiri kua pā, me te whakatika tipare. Hoki te pānga mōrahi, ka taea e koe hipokina tākai ki te takai kirihou.
• Ki te whakaaro ano, ka taea te whakamahi i te wai hou te decoction o rau Ongaonga ranei. Tākai hanga o te kaupapa i runga ake-whakaahuatia.
• pemphigoid Bullous, ranei atu ïa, e taea te fakafiemālie'i'a ona tohu ki te decoction rongoā motuhake. Ki te hanga tango reira he nui rite (50 g) o rau Eucalyptus, rhizomes pōkai Sophora hua japonica, puku birch, yarrow, putea o hepara, me te ongaonga. E rua punetēpu o te ranunga rite i roto i te otaota ahiahi, ringihia he karaihe o te wai kohua, me te waiho te pō. I te ata o te whaowhia he tika ki te tatau me te wehe ki toru nga wahi - tango ratou i roto i te ra.

Kei te matau te reira e kia mahi rongoā otaota mō ia manawanui rerekē. Ahakoa, ki te he pānga pai te kaihoko, i roto i tetahi take e kore e hoatu e ake maimoatanga hauora.

Ko te waitohunga mō ngā tūroro

Pemphigoid - he mate Koló o te kiri, a na reira e wahi i roto i te nuinga o te wā he kore rawa pakeke. Ano, tata whakamana tetahi hōhipera pa nui he ingoa kia uaua te maimoatanga angitu mo te mate - pemphigoid bullous. I roto i Orenburg, Moscow, me tetahi atu pa, e mohio ana ki te kitea i te mātanga pai koutou. ka whakawhirinaki wahi o te noho i runga i anake te utu o te maimoatanga, mai rerekē te utu o etahi rongoā i roto i te rerekē tūemi rongoā.

A, no te whakahaere tika e taea e te maimoatanga te whakatutuki i te murunga pūmau. Mai i te wā wa ki reira e matahoki etahi tūroro, i, o te akoranga, kino, engari e kore e mate. I te tahi atu te ringa, i te mea kahore wahi maimoatanga o te hanganga o pāpaka kia meinga he kuwaha mo te mate, aua oti mumura atu nui, suppuration o patunga, kookuhutanga o huakita pathogenic ki te paparanga kiri hohonu.

He reira tetahi tikanga o te ārai?

Kia aroha mai, i reira he kore rawa motuhake mō te ārai i taua mate rite Lever pemphigoid bullous. Noatia, he mea nui ki te rapu i te tauturu i roto i te wa, me rite te mate ma'i, ara i roto i wā o whanaunga pai-oranga Me ki āta aroturuki i te āhua o te hauora.

Kaua e wareware i anga te mate i roto i te rongoa kei te rite te tohu mate pukupuku pea. Ko Ko te aha te aroaro o te mate me waha te manawanui he whakamātautau whānui ki te whakaū i whakahaere tikanga i roto i te tātaritanga o Cancer ranei. Kia mahara ki e ki tetahi mate he nui māmā ki te akakoromaki, ki te tīmata koe i maimoatanga wawe.