Methylation DNA: te tirohanga whānui

Methylation te te hono o tetahi waro, me te toru hauwai ngota ki tetahi atu rāpoi ngota. whakaaro ana tēnei āhuatanga te ki hei te kupu whakamutunga i roto i te tiaki hauora. Kei te haere tahi ana ia e te whakatinanatanga o tata katoa mahi tinana.

mahi

E whai wāhi ngā rōpū methyl (waro, me te hauwai ngota) i roto i:

1. whakautu o te tinana ki ngā āhuatanga taumaha.
2. Whanaketanga me te tukatuka o glutathione. E ohipa te reira te antioxidant matua i roto i te tinana.
3. hormones detoxification, konganuku taimaha, me pūhui matū.
4. Whakahaere tukanga inflammatory.
5. Hanga pūtau pakaru.
6. whakautu ārai me te ture ki huaketo me mate, hanga i te mana o T-pūtau.

. E rite nui ko te tukanga o te DNA methylation. Kia whai whakaaro ano tatou i te reira i roto i te kōrero atu.

mana Epigenetic o

способствует передаче паттернов следующему поколению клеток при митозе. tauira DNA methylation whakahaere te whakawhitinga o te whakatupuranga i muri o ngā pūtau i roto i te whāū pūira. Āhua tata, kua kitea taua mea e te tukanga o hono rōpū o ngota i roto i nga hanganga ma'ie te-rerekëtanga kua etahi hononga ki te hanganga o te mahara, me te plasticity synaptic. K. Miller uiui, a D. Sweet DNA methylation. Hono ako i te āhuatanga arahina ratou ki te faaoti e dezoksiribonukleinovokislotnoy tino nui haere te mahi o te methyltransferase i roto i nga kararehe i roto i te tamau aau mōhiohio hou. E āwhina ana tēnei whakaiti i te faaiteraa o ira e pehi i te tukanga mahara. I tua atu, tohu nga kaituhi ki tetahi atu mea. pūrongo nga kairangahau e te ira whakahohenga pūmua reelin, whakatairanga huringa me hononga synaptic wāhi i roto i te akoranga pathological o tuakoi pānga hanganga mahara. A, no te makatu'unga tenei take te demitalazy-whākōkī whakarato i te demethylation DNA (tuku i te rōpū mewaro). meka whakapumautia arata'i ki te mutunga nui. , а также обратное ему явление, играют существенную роль при хранении информации и запоминании. methylation DNA rite tetahi o nga tikanga epigenetic, me te te tītohunga kōaro, te tākaro he fatongia mahu'inga i roto i te rokiroki mōhiohio me te mahara. I whakapumautia tenei whakaaro i te hua o te rōpū ako E. Costa. I kitea te reira e taea te makatuunga demitilirovanie reelin me glutamate ira decarboxylase kiore rāpoi iti e pokanoa ki te DNA tipu i roto i te karihi. Enei akoranga tohu te taea e kore anake o te huri ngā whakaaro ngā pā ana ki te hanganga o te mahara. является динамическим. tohu ano ratou ki te meka i he hihiri whakaaro i mua methylation DNA tūturu. Ano, e taea te whakamahi i te reira i roto i te therapy.

āhuatanga

имеют определенную связь, нельзя назвать новой. Ko te whakaaro e mahara me te DNA methylation i te tetahi hononga, e kore e taea te huaina hou. Kua oti kē whakapumautia te reira i conditionality synaptic tuku histone acetylation. hanga ana e ratou te kōhiwi i runga i maru ia i te DNA te. Acetylation whakaiti te marena o te histone ki waikawa karihi. oroko uru ki te DNA me te tahi atu pūmua e pā ana ki, tua atu i ëtahi tenei, ki te faaitoitoraa o ira. I roto i te meka, te CREBBP atsetilotransferaznaya mahi histone (here pūmua), mahi rite he neurons tauwehe te tuhi matua i pā ana ki te pānga o tenei pūmua i runga i aauraa. I tua atu, i whakakitea ai mahara pūāhua roa amplification i roto i te whakamahi o inhibitors histone deacetylase. arahina te reira ki te whakatere o histone acetylation.

whakapae

ka ui Sweet ko Miller te pātai e whai ake nei ki te whakapai kanohi ki te pehanga histone-ti'aturi o te tauira whakapuaki. ? Ki te taea te tākaro te reira i te wāhi i roto i te mahara ture, ka arahi ki te pānga taua ranei DNA methylation? I kitea tēnei āhuatanga matua rite te tikanga o te pupuri i ngā mahi i roto i te whāū pūira me te hanganga hanga pūnaha. Heoi, i roto i te roro kararehe pakari methylases kaha kitea, ahakoa te meka e te nondividing te nuinga o nga pūtau. Nā ki te meka e whai wāhi te āhuatanga whakaaro ki pehanga o te whakaaturanga ira, i taea ki te whakakahore i te methylase tūponotanga kōrero me ngā tukanga ture i roto i neurons kairangahau.

Taki whakapae

этого явления в формировании памяти, обрабатывали срезы гиппокампа ингибиторами дезоксирибонуклеинокислотных метилтрансфераз. Sweet me ana hoa mau e ui ki te methylation o DNA, te hiranga o tenei āhuatanga i roto i te hanganga o te mahara, poro hippocampal tukinotia ki inhibitors dezoksiribonukleinokislotnyh methyltransferases. kitea ratou e ārai reira te timatanga o te potentiation wā roa-- te whakapakari o hononga synaptic i roto i te whakautu ki te mahi neuronal. Tenei tukanga ai te pānga o te ako me te mahara tikanga. Kua kitea hoki Scientists e heke inhibitors taumata o methylation i DNA reelin. tuhu reira ki tona ànui.

ngā

Whakatau ki te haere atu i roto i o ratou akoranga, ka timata Sweet ko Miller ki te aroturuki i te huringa i roto i te tauira methylation i roto i te kiore i roto i te tauira i roto i nei ako kararehe ki te pāhono i te wāhi motuhake ki akiaki kino, i roto i ngā, puranga ngoikore. Whanonga inhibitors te whiwhi whakamātau, faaite te taea o te fifi akoranga. Kimihia ratou i roto i te āhuatanga i reira i ratou ki te waiho i te wehi, piri ratou tino iti iho i te kararehe mana.

ngā kitenga

Pehea i taea e methylation pā te mahara o kiore? Kua faataa pūtaiao tenei e whai ake. Ko reira te DNA te rota o wahi e taea pā rōpū hono o hauwai me te waro ngota. I roto i tenei whakaaro, faaoti te kairangahau ki te tono ki te āhuatanga e whai ake nei. ako ratou matua methylation o ira nei tūranga i roto i te hanganga o te mahara kua whakaturia. I tangohia tuatahi ia ake te wāhi i runga i nei e tāmia te tukanga mahara pūmua phosphatase. faaiteraa te heke haere taea meinga te pānga ritenga. Ko e mo'oni, kotahi haora o conditioning horopaki taumata wehi methylation neke atu i te rau nga wa nui haere. I roto i tenei take, nga taumata mRNA i hippocampal rohe CA1 i raro ki te whakaiti ngoikore, engari tauanga nui. kitea ana tēnei pānga i roto i te roro o te kararehe ki te huinga o puranga iti ki nga topito me te horopaki o te minamina ana. Wehe, e kore e enei mau tumu whakarato i tetahi pānga i runga i methylation. Nä, kawea te rōpū hono kei roto i anake ki te whakaako reira.

methylation DNA me te hoholo

Raruraru o tau me te ahua o te mate pukupuku, ko tetahi o nga kaupapa tino kōrero. Neke atu i te maha nga tau o te rangahau, kua fokotu'u kaipūtaiao he momo o ariā me ngā tauira. Heoi, e kore e kore te ariā i te kau whakautu tino ki te pātai katoa. Na, ko te moni rahi i roto i te rapu hoki rongoā ko te ako o te toulekeleká huringa i roto i te mahi ira. I roto i ngā, tona whakaaro i runga i te mea kī Ahorangi Anisimov. tohu ia i roto e te faaiteraa (faaiteraa) o ira he ti'aturi, i roto i era atu mea, i te methylation, e taea pā te auau o te hoholo. Whakatika ki te 5% o ngā toenga cytosine o te waikawa deoxyribonucleic hono i ngā rōpū o te waro me te hauwai ngota ki te hanga i 5mTs (5-methylcytosine). whakaaro ana tēnei turanga te ki kia anake te tamau i roto i te DNA o kaiao teitei. Hono rōpū e wahi i rua whenu symmetrically. Tonu huna tonu 5mTs muri nga toenga guanine. I roto i tenei hanganga i mahi rerekē. Heoi, he mea nui ki te mōhio he wāhi i roto i te ture o te mahi ira taua methylation. Huringa i roto i te akoranga o ngā rōpū hono meinga e rahunga i te taumata o te patohanga.

take

i whakaahuatia tuatahi Age-demethylation i roto i 1973. I kitea tenei rerekētanga tohu o te wehenga o ngā rōpū i roto i te kopa kiore. I roto i te roro, ka haere demethylation atu kaha atu i roto i te ate. I whakaritea muri reira 5mTs heke ki tau i roto i te pūkahukahu, me te ngā fibroblast kiri. fokotu'u mai nga kairangahau e auroro pūtau ki te hurihanga mārere te tau-demethylation. Ka taea te faaite i tēnei āhuatanga i roto i ngā faingofua e whai ake. I honoa He ira tautauā ki rōpū methyl. I raro i te mana o te tauhohe matū haere i runga i tona momotunga. Nä, whakahohe te ira te. Rōpū mahi nga mahi o ngota wiki. Ko te iti te tokomaha, nga pūtau atu rerekëtanga me te kupu pakeke atu i to ratou ake - na ko reira teina. Kei te whakamahia whānuitia te tauira matarohia i roto i te tuhinga, ka taea e hua i roto i te whanaketanga o etahi momo o karaka. He āhuatanga o ratou mate tino tere tonu i muri i te waa. tonu mate Nonanahi takitahi taitamariki o tau uri i roto i te wa poto. I roto i te mahere koiora, whakatere tenei tītohunga te hoholo, haere tahi nei i nui-tauine demethylation DNA.

Me pēhea te ki te āwhina i te tinana?

He ngā tikanga e ai ki te whakapai ake i methylation DNA hohonu. I roto i te rongonui tino kia huaina:

1. Kai greens hou. E rawa tūtohutia huawhenua pururu. mahi ratou rite te puna o te waikawa folic hiahiatia ki te whakarite methylation tika.
2. Vitamins B12 me B6, Huapuhuikowhai. Ratou puna he hua, ika, aramona, wōnati, apareka me te pera i runga i.
3. Te fariiraa i te nui rawaka o te konutea me te konupora. whakarato rātou i tiaki methylation.
4. probiotics Te Uru. whai wāhi ratou ki te whakarite me te absorption o huaora rōpū B me te folic ki-koe.

He mea nui hoki ki te whakaiti te ahotea, hoatu ake peu kino (te kai waipiro, kai paipa). kia Care kia tangohia kia e kore i te tiki i te tinana te taonga paitini. Ēnei pūhui tango utaina rōpū methyl ate.