"Octagam": tohutohu mō te whakamahi, tohu, pānga taha

E pā ana te reira ki te tarukino e whakarei ake te pūnaha ārai mate, "Octagam". ka Ture e haamana'o e te mea he tarukino nui tenei, a kua whakaurua reira anake i roto i te hōhipera, tino i runga i whakahaunga. Whakamahia rite whakakapinga, me te maimoatanga immunomodulatory.

Puka tuku i te tarukino me tona hanganga

Kei te whakaputaina te reira i anake i roto i te puka o te otinga mō te whaowhia faaineineraa "Octagam". Tohutohu piri ki reira, ka he kaupapa ki te ako whakahauanga i mua i te tono. He mārama te otinga, me te urukehu kowhai. whakaputaina te raau i roto i oko karaihe 20, 50, 100, 200 ml, e kua katia ki te puru rapa me te burnishing konumohe Kikī i roto i te pouaka pepa, te wahi i roto i te tua i te tohutohu mō te whakamahi ko te taata tei mau kirihou-mata.

Kei roto i te medicament i te 1 ml o te iti rawa 95% immunoglobulin G. he ōrite ki te nui o te pūmua i roto i roto i te wē toto tangata te tohu. matū atu i roto i te hanganga o te tarukino ko:

• maltose;
• octoxynol;
• tributyl Phosphate;
• wai mō te werohanga.

E kore e te tarukino whakatio maka atu ki te rā ranei. Kei te rongoa reira i te pāmahana o te 2-8 ° C, te taea o ngā tamariki.

Pūtaiao me te pharmacokinetics

Drug "Octagam" (faaara ā e pā ana ki contraindications me mau hopearaa taea o te whakamahi o te raau taero) pānga te pūnaha ārai mate te tangata, me te pā ki immunoglobulins.

Rongoā ko te wahi o te piha haapiiraa immunoglobulin G, e hua paturopi ki ngā tukanga hopuhopu i roto i te tinana. Kei te tarukino subclasses o te immunoglobulin G, ōrite ki te wē tangata, faahiti katoa o ona āhuatanga me ngā āhuatanga. Ko te kupu whakataki o te tarukino ki te tinana Kia whakahokia nga taumata iti o IgG, arata'i ia ki te āhua tonu. rāpoi IgG tika ki enzymatic me te rongo matū kihai i puta ke. Ko te mahi o te paturopi i taea ki te rawa whakaora.

I roto i te faaineineraa e kore he "Octagam" neke atu i te 3% polymer, whakairia te toenga e hoki e waetahi me dimers ko e pā ana ki 90%.

A, no te hanga koe i te taputapu e whakamahia ana te toto o 3500 kaituku tino hauora. Paturopi i reira i roto i te wē o enei iwi i noho i roto i tenei faaineineraa tonu me noho itoito.

I muri i whakahaere tarukino ki te immunoglobulin rua tomo tonu G te tohanga nahanaha, tohaina nei i waenganui i te wāhi iaia me te wē. I roto i te tono i te "Oktagama" ake huru o te manawanui i roto i 3-5 ra. Ahu rongoa i 24-36 th ra. he rerekē hoki te katoa te hawhe-te ora, me te tei runga i tau o te manawanui, tohu o ārai. Immunoglobulin G ranei te tahi atu complexes ārai kei roto wae kaha, huna e te pūnaha reticuloendothelial.

A, no te whakamahi i "Octagam"?

Tono "Octagam" whakakapinga therapy, ka i reira he syndromes tuatahi ārai, te tuatahi o te katoa, he hypogammaglobulinemia congenital, agammaglobulinemia me Wiskott-Aldrich syndrome. Kei roto i tēnei tāupe momo ārai unclassifiable me immunodeficiencies ngā.

tikanga te tohu mo te tarukino te myeloma maha, lymphocytic puka ma'i. rongoā whakaritea hoki tūroro ki mate recurrent, me te tātaritanga o HIV i roto i ngā tamariki.

Kua kitea e te rongoā tona whakamahi i roto i whakaora. Ko, kua whakamahia te reira i roto i idiopathic te purapura thrombocytopenic (ITP), tahi e te kaha ake te tūpono o te toto. Ano, whakamahia te raau e te aroaro pokanga ki te haerenga, tatau mōtepe. I whakaritea rongoā ki Guillain-Barre syndrome. tavini te reira hei tohu mo te mate Kawasaki i roto i ngā tamariki me ngā pakeke.

Whakamahia "Octagam" (tono Kaiwhakamahi whakaahua ana i roto i te taipitopito te tikanga o te whakahaere me te inenga o te tarukino) i roto i allogeneic transplantation wheua wheua.

Contraindications mō infusions

faaara te reira e ko te reira e tika ana ki te tango i ki contraindications pūkete i mua i te whakamahi "Octagam" tohutohu faaineineraa. Kaua e whakamahi i te rongoā i roto i te aroaro o te hypersensitivity ki ona matū wāhanga ranei ki immunoglobulins huirua.

Ki te tiaki rawa whakarite tūroro te tarukino nei e mōmoma. E ratou he predisposition ki te whakawhanake Thrombosis. Tikanga contraindicated te ki reira te mea he "tātaritanga o takawhita," te mate o te mate huka, mate o te pūnaha Cardiovascular, i whakaputa noho kahore waka, ake i roto i te pokey o te toto.

A, no te tomo i te pokey tiketike o te wē immunoglobulin, te bloodstream, whakapataritari i te mōrea o te infarction myocardial, Embolism pūkahukahu, patu, Thrombosis venous.

Me whakamahi Whakatūpatotanga tenei tarukino, tūroro ki täkihi me tūroro ki hypovolemia manawanui maimoatanga āpiha nephrotoxic. Ki te kahore he he whakahaere whakapeka o immunoglobulin-atamira mate tākihi, mutu te "Oktagamom" therapy te.

Tūroro ki täkihi whakapeka i roto i te āhua me te iwi ki te pōauautanga thromboembolic o honikoma rō-uaua werohia ranei, faaterehia te tarukino te āta, me te i roto i te moni iti.

Ko te mana o te tarukino i roto i nga wahine hapu, a lactating kihai i i ako, na tohu nga wā kia whakamahia rongoā ki te tūpato tino. Ahakoa tenei, whakaatu ana te mahi e kore e te whakamahi o immunoglobulins puta tetahi pānga kino i roto i te hapūtanga. Te raau e kore pānga i runga i te kukune, a e kore e pā te tamaiti i roto i te waiu o te whaea. Immunoglobulins, whiwhi ki te waiu uma, e kore e meinga tetahi kino ki te hou, a ka roto nga paturopi reira, whai wāhi anake ki te hanganga o te wātea i te mate kaha.

inenga

"Octagam" faaterehia te raau e pâmuhia anake. I mua i te tīmata ki te kia mahana ki te pāmahana rūma, te tukanga otinga. Me kia tino mārama te wai, me te whai i kahore hohenga, me te turbidity.

tuhia i ia whakahaere tarukino te i roto i te aamu o te mate. He hanga hoki tau tarukino puranga me te ingoa. meatia tenei e ki te whakapai ake i te aroturuki o te huru o te manawanui. Te raau e toe i muri i te whaowhia, e kore e taea te rongoa me me ngaro.

Ko te auau tuatahi o te whakataki sostvlyaet 0.01 ki te 0.02 ml / kg taimaha tinana i roto i te meneti kotahi, a pera i runga i mo te hawhe haora. Ki te auau medicament tolerability pai āta taea te nui haere ki te 0.12 ml / kg taimaha ia meneti tinana.

kua oti te whakarite te nui o te tarukino me te roanga o te therapy takitahi hoki ia manawanui. Tei mea katoa i runga i te whakautu haumanu i roto i te manawanui ngā, tona huru me te tātaritanga o te mate.

Whakauru immunomodulating therapy i roto i te ārai tuatahi ngā te whakanui ake moni o immunoglobulin G ki te 4.0-6.0 g / l, i whanganga reira i mua ki ia whaowhia. I roto i te tikanga ki te whakatutuki, ka rapua e 3-6 marama o te maimoatanga he mea whakaahua taua. whakahaere horopeta tuatahi ko 0.4-0.8 g / kg. I muri te whakahaere te tarukino ki te tūroro i nga toru wiki i 0.2 g / kg. Hei whakatutuki i te ūnga immunoglobulin 6.0 g / L, me kia whakanohoia te manawanui i runga i marama 0.2-0.8 g / kg o tarukino. Kia te hoki manawanui ki āhua noa, tonu te tarukino ki kia whakahaerea nga 2-4 wiki, i muri i ine i te kukū o te immunoglobulin G i te toto. Tenei e te tauturu ia whiriwhiri koe i te inenga tino pai.

whakahaere whakauru rongoā therapy te i roto i te kanisā lymphocytic ma'i, e haere ki te hypogammaglobulinemia tuarua i roto i te puka kino, i roto i te myeloma maha, kia rite ki te pai kia rite i roto i te tātaritanga o "HIV pai" i roto i ngā tamariki ki te recurrent, me ngā tukanga hopuhopu. Inenga kupu fluctuates tawhio 0.2-0.4 g / kg. Liunga whakataki - katoa 3-4 wiki.

I roto i te maimoatanga o wā tāhapa o te purapura thrombocytopenic idiopathic (ITP) whakamahia te i roto i te inenga o te tarukino 0.8-1.0 g / kg ka whakahaere i te ra tuatahi. Ki te tika, te anō o medicament whakaputaina i 2-5 ra i roto i te nui o 0.4 g / kg. Ki te auau take o exacerbation o te mate, whakahaere ano te tarukino te.

Guillain-Barre syndrome maimoatanga tā i 0.4 g / kg o te tarukino ia ra mō te 3-7 ra. I roto i tenei take, he tino iti te whakamahi o te tarukino mō ngā tamariki.

mate Kawasaki i roto i ngā tamariki me ngā pakeke peratia ki te inenga o te 1.6-2.0 g / kg. whakahaere te raau i roto i te horopeta taua i runga i 2-5 ra. Whakaaetia waihanga tarukino kotahi i roto i te nui o 2.0 g / kg. I roto i te maimoatanga haere tonu o te manawanui tukutahi ki te whakataki o "Oktagama" e tika ana ki te whakamahi i ahipirini.

whakamahia immunoglobulin te i muri i te wheua allogeneic wheua transplantation maimoatanga faaineineraa. Whakahaere o te tarukino ārai te takanga o mate, me te whanaketanga o te syndrome o "uhi versus ope". whiriwhiria te inenga mō ia manawanui te takitahi. E tūtohutia ana kia tīmata i te horopeta o 0.5 g / kg ia wiki. kia timata werohanga tukanga he wiki i mua i te transplantation okana ka ū mai. tonu therapy mō te toru marama i muri i te pokanga. Ki te reira te mea he kore tamau o immunoglobulins, te rongoa whakamahia ki te 0.5 g / kg marama katoa hoki rite te roa rite kore e ratou ihirangi hoki mai ki ngā taumata noa.

pānga taha

Kaupapa ki te ako whakahauanga i mua i tono rongoā "Octagam" ā-ako. Ko te whanaketanga o ngā pānga taha, ka whakamahi i te raau taero tei runga i te horopeta me auau o te whakahaere.

werohanga rō-uaua ki te tarukino e taea meinga leukopenia, hemolysis me reversible anemia hemolytic. I roto i te maimoatanga o te tauhohenga kino ka taea o te pūnaha ārai mate, e kua whakahuatia i roto i te faaiteraa o te hypersensitivity. I roto i te wā onge whakatika anaphylactoid me tauhohe anaphylactic, puffiness o te mata, angioedema.

HIV therapy i roto i ngā tamariki, me te maimoatanga o te tahi atu mate maha ai pāhoahoa. Ko reira onge whakararuraru, roro o toto tohanga, te oaoa nui, kiriuhi iroiti. Ka taea e te raau meinga ānini, paresthesia me te taninito.

I roto i te maimoatanga, i reira te mea he tūponotanga o takanga o infarction myocardial. He pea he nui haere mokowhiti me tahikradiya. I te tahi taime māharahara cyanosis, hypotension me Thrombosis. Ko reira tino onge iti hoki circulatory, Thrombosis rua hohonu, takawhita.

Ka taea e te tarukino meinga te tauhohenga kino i runga i te wahi o te pūnaha romahā. Tenei kore romahā, edema pūkahukahu, hāhā o te manawa. E faaite te mau hopearaa ino i roto i te pai o te maremare, bronchospasm, Embolism pūkahukahu.

Ka taea e te maimoatanga meinga whakapairuaki, ruaki pūpū, mamae puku, korere. I roto i te wā onge, i reira he katoatia, urticaria me te minamina. I roto i te tahi mau tūroro, i muri i te whakamahi i te tarukino whakatika dermatitis, alopecia, me pruritus.

Kei te uaua kitea te reira i tauhohe pēnei i te mamae i roto i te rohe hoki, myalgia me arthralgia. Ētahi atu i roto i te maimoatanga kia whakawhanake iti hoki tākihi, nui haere creatinine serum, whakakorikoria kirika, rohirohi tino, puta hūhi tauhohe i te wāhi i werohia. I roto i ngā taupetupetu kino kitea Chills, mamae i roto i te pouaka, te Makere, ahuatanga, ponana me te pyrexia. I roto i te āhuatanga onge, tūroro i pēhanga toto iti, ru anaphylactic.

Ko te ahua o ngā pānga taha taea i roto i tūroro, whakahaere o te raau taero nohotahi mua pai. "Octagam" ai he hua i roto i whākōkī ate me nohanga kūhuka i roto i rangahau taiwhanga toto.

A, no te tīpakohia tika kia puta horopeta overdosing tohu. Ko te nuinga o te reira i pupuri inu i roto i te tinana, whakanui i te toto pokey, kitea nei i roto i te takitahi ki te mate tākihi, a i roto i tūroro paari.

I roto i nga wā i runga katoa, tūtohutia maimoatanga symptomatic te.

Ara

taea ki te whakaiti i te pānga o ora kano huaketo attenuated mo te wā o te ono wiki ki te toru marama te tarukino ko. Hei karo i tēnei, kia tatari koe i muri i te tono o te toru marama o te faaineineraa "Octagam". te whakaiti rongoā te whai huatanga o karawaka kano i te tau, na mua i te atamira o tenei werohanga kia tirohia karawaka titer paturopi.

Maimoatanga ki tenei tarukino e taea meinga he maha o ngā pānga taha, koia ko reira tika ki te ū tino ki ngā tohutohu mō te inenga me te auau whakahaere. I roto i te akoranga o te therapy he tika i ki nga wa katoa aroturuki i te hauora o te tūroro.

kia riro tūroro e faaterehia immunoglobulin rō-uaua, rawaka hydration mua ki te tukanga, ki te whakahaere i te aroturuki o te putanga mimi me te creatinine toto. He mea tika ki te tango i te katoa te tono o te "koropiko" Diuretics.

Ki te mea i reira e tika tauhohe tōraro ki te whakaiti i te auau o te whakahaere tarukino ranei tino mutu te whakamahi i te reira. Tei katoa te therapy i runga i te pakeke me te āhua o ngā kino. Ki te reira te mea he ru, he mea e tika ana ki te huihui ki anti-ru therapy, e kia ngā ki te maimoatanga.

Tino maha ai tauhohe kino auau tere o whakahaere, rawa i roto i hypo- me agammaglobulinemia me te tono immunoglobulin tuatahi. kia puta pānga te taha, ka whakawhiti i te manawanui ki te immunoglobulin kotahi kaiwhakanao ki tetahi tarukino, me te mea kua haere te rota o te wā mai i te whaowhia whakamutunga.

kia kawea Mana o enei tūroro (me tenei ngā tūroro ki te tūnga HIV-pai) i roto i tonu puta noa i te wā o te whaowhia tuatahi o te mahi, tautautefito ki he lolotonga te haora tuatahi i muri i te tukanga. Tūroro e kahore pānga taha, kia waiho ai i raro i te tirotiro o te tākuta i muri whaowhia "Oktagamom" te 20 meneti tuatahi.

I roto i therapy kia tango whakatūpatotanga paerewa ki te ārai mate e ka taea ina whakamahi i rongoa i hanga i te toto wē ranei te tangata. Ko ētahi o ēnei ko te kōwhiringa o ngā kaituku e tika ana, te aroturuki o tohanga takitahi me harotoroto wē mō tohu motuhake o te mate. Me uru tēnei tukanga mehua mo te inactivation / whakakorenga o huaketo.

Ahakoa nga whakatūpatotanga katoa i roto i te maimoatanga o taua raau taero, e kore e taea e tatou e tutakina i te taea o te whakawhiti o te maha o māngai o mate, huaketo me ētahi atu tukumate. Katoa o nga mehua runga ake mahi i roto i te faaotiraa o wheori hipoki HIV, kakā B me C. Ko te iti rawa whakatau ratou nga kawe o parvovirus B19 me gipatita A. wheako Haumanu o āpiha maimoatanga kei roto immunoglobulin tangata fokotu'u e B19 parvovirus me te kakā A i roto i te maimoatanga o taero e kore tuku raraunga. O faufaa nui i roto i te haumaru huaketo ko te aroaro i roto i te hua rongoā hāngai paturopi.

I roto i te wahi o te akoranga haumanu kia hoatu paturopi pē whakawhiti i roto i te toto o te manawanui hua teka ina mau ana i roto i ngā whakamātautau serologic. Maltose roto i roto i te takanga Ko te ahei o ketia teka te taumata toto kūhuka.

mahi whakarei i roto i te toto kūhuka kukū kitea i roto i tango o te raau taero i te rauropi rima haora i muri i tona katinga ranei. I roto i tenei take, i reira he he pea o hē whakaaro taiāki horopeta e taea whakapataritari e suka. Na reira, anake tikanga glyukozospetsificheskie mō te whakatau i te taumata o te kūhuka i roto i te toto ki te kia whakamahia i roto i te maimoatanga o "0ktagamom". kia taea ki te whakatau i tēnei tawhā i roto i tūroro tango rongoā ki maltose kete Test mō te huka toto aroturuki.

Ki te kore te takanga, ka whakaaetia ki te rokiroki taero "Octagam" (50 ml me 100 ml) i te pāmahana ki runga ki + 25 ° C mō te toru marama, kahore Tuarua whakatakoto i te reira i roto i te pouaka whakamātao. Kāore hoki te wa i whakaritea, me te tarukino kia ngaro.

e kore e rongoā pā te kaha ki te pei a ki te mahi mahi e rapua e pahure tokanga makehe me tauhohe whakamātau tinana tere.

Drug "Octagam": ritenga

he maha o analogues e taea te whakakapi i ia i roto i te take o te hiahia tenei rongoā kua, ko reira:

• "Biaven VI."
• "Veegum-tere."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma Globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

He nui iti atu o ratou ritenga ke whakakapi Russian. I roto i tetahi take, he nui nui ki te tiki ake i enei taero katoa a me whakakapi anake i te tākuta, e hāngai ana i runga i te huru o te manawanui.

"Octagam" Medicine: utu

Ko te utu o te tarukino ko tino nui. Ka taea te hokona te reira mo 9,5-12 mano moni, me te 50 ml o te tarukino "Octagam". 100 ml Utu ko a tawhio noa 20-24 mano moni.

Ko nga whakaaro o tūroro me rata

Drug "Octagam" He arotake te nuinga pai. Rawa mauruuru ona iwi kounga, nei i tauturu ia ki te ora ki te ārai me te Guillain-Barre syndrome. Kei te maha whakamahia te reira no te iwi ki a AIDS mau tonu ratou hauora. whakamatauria e ia ki te kia whai hua i roto i te kanisā lymphocytic ma'i, gravis myasthenia. whakamahi Women tenei tarukino ki riro hapu, me te mau i te tamaiti.

Te nuinga o nga tūroro wenewene te utu o te raau taero, mōhio ratou e he uaua ki te hoko i roto i pharmacies. huaina etahi reira he ngoikore, ānini, me ahuatanga whānui.

Doctors mea e ko te reira i te faaineineraa parakore, Kei te pai riro te reira i te tinana, a rite ki immunoglobulins kāinga iti pea ki te meinga mate pāwera.