Lipid peroxidation (AHW) ko te hononga faufaa i roto i te utu pūkoro. Ko te mahi taketake o reira ko ki te whakahou i te lipids o kiriuhi pūtau.
I roto i te peroxidation tangata lipid hauora whakahaeretia e te pūnaha antioxidant pera-ka karanga nei regulates te mahi tere, me te phosphorylation mā te here āhuatanga mahi whakapataritari ranei e haamou i te nui o peroxides ki te ārai i te maha atu o ngā hua mutunga o pākia. kia tukanga pitihāoratanga Amplification te wāhi tīmata i roto i te tukanga pathophysiological moni nui mate. I tēnei tukanga ngā te taahiraa o te enzymatic me autoxidation kore-enzymatic.
momo
Hei whakarerekē i te bilayer phospholipid o te membrane pūtau whakawhānui hāora enzymatic. I tua atu, kua whai wāhi te reira i roto i te hanganga o matū kaha biologically, detoxification, tauhohe pūkoro tinana. e faaite ake rite te take kino i roto i te ora o te pūtau pitihāoratanga Non-enzymatic. Nā ki te hanganga o nui o Radicals free me peroxides whakaeminga antioxidant heke mahi pūnaha me rite te putanga, i reira he whakangaromanga o ngā pūtau rauropi.
huringa PAULO
Hei tīmata lipid peroxidation aroaro tika o te hāora Radicals free, he te taumata pūngao i te tino kotahi irahiko unpaired. I muri i te ora o ngā rāpoi ngota hāora hua superoxide e tauhohe ki ngota hauwai, tahuri ki te hauwai. Hoki te whakahaere i te nui o superoxide roto pūtau tīari dismutase superoxide, hanga hauwai me catalase, peroxidase e haamou i te reira ki te wai. Ki te i kitea he rauropi ora ki ionizing radiation, ka whakanui ake i te maha o noa Radicals hydroxyl tino. I tua atu hāora waihā me ētahi atu ona momo kaha kia kōkiri i te tukanga whakaoho o peroxidation lipid.
Products o lipid peroxidation kaiao tikanga o, whakamahia mo te kōtuitui o prostaglandins (matū whai wāhi i roto i te tauhohe mumura) ranei ranei, thromboxanes (ngā Niniiraa thrombogenic o tauhohe), hormones adrenal.
pūnaha mana
Tei runga i te tere turanga hanganga membrane pūtau, me te nui o te mahi o nga hua hāora hua kia rerekē. Hei tauira, te mahi o lipids peroxidation runga ake i reira te nuinga he wahi o te taiepa pūtau te waikawa ngako hamanga, ka pōturi, ki te te pūtake o te COP he cholesterol. I tua atu, take te whakahaere i te nui me te auau o te hanganga o Radicals hāora free, me te whakamahi o peroxides, he whākōkī pūkoro tinana. Ahakoa i roto i te tauhohe o lipids peroxidation whai wāhi matū e pa i te membrane pūtau lipid hanganga me te huringa noho i roto i runga i te hiahia o te rauropi. Ko ētahi o ēnei huaora E me te K, thyroxine (thyroid taiki), hydrocortisone, cortisone, me te aldosterone (o te urupare). katote konganuku taiepa pūtau destabilizing, huaora C me D.
takahi o te tukanga
kia whakaemi hua pūkoro tinana o te lipid peroxidation i roto i nga kopa me fluids tinana te kore e kore e pūnaha antioxidant te tuku o ratou ki te tere e tika ana. Nā tēnei hono fakahohaasi waka o katote puta noa te membrane pūtau, e autaki kia whakaawe i te hanganga ngota katote o te wahi wai o toto, te tere o te vahiraa me depolarization o te membrane uaua pūtau (whatiia āriponga o ponana karere, ratou contractility, roa te wā tutu), te whakahaere i te tomokanga o te wai ki roto ki te wāhi wahopūtau (edema, clots toto, kawehiko tāne i). I tua atu, i te hua matua o peroxidation lipid, i muri i te raupapa o ngā tauhohe matüora, e tahuri ki aldehydes, ketones, waikawa me pera atu. Ēnei matū i te pānga paitini i runga i te tinana, i faaite ake i roto i te auau whakaiti o DNA kōtuitanga, whakanui i capillary uruhanga, whakanui i te pēhanga oncotic, rite no reira, Koinei-syndrome.
Faaiteraa i roto i te whare hauora
Mai te hua o te hāora noa Radicals he pānga e totohu i runga i te taiepa pūtau, me nga hua pūkoro tinana whakapōrearea i te pākia me ariā o waikawa karihi, me te paihana te tinana, he ratou take pathophysiologic i te whanaketanga o te maha o ngā āhuatanga haumanu. Ko te tūranga o te peroxidation lipid i roto i te ate, ko te mate nui o te hononga, Parasitic mate hopuhopu, disorders hemodynamic, mate oncological, traumas me weranga. POL Ko tetahi o nga āhuatanga mō te atherosclerosis. Radicals Free oxidize cholesterol me ona iti hautanga taimaha rāpoi ki te hanga i ngā hua e tūkino i te taiepa iaia. Tīmata tenei he Niniiraa o tauhohe pathological angamaheni ki te whakatutuki kino. whakaoho tenei clots toto, haaputuraa o clots toto i roto i te lumen o oko iti ranei tāpiritanga ki ratou taiepa. Ka rite ki te hua o te kaupapa o te toto i roto i tenei rohe pōturi iho, rite kua kua riro he lumen oko. whai wāhi ana tēnei ki te haaputuputuraa atu o clots toto. Ko te tino haria ki taua huringa i roto i te iatuku pūngākau, te haoraora, whakakitea i roto i te tohu whare hauora o te mate coronary o te ngakau.
āraihia
Me mahara ngā e taea te whakahaere o ngā tukanga tātaritanga, me te whakaora whakahohe i te huarahi o te lipid peroxidation. kia whakatupato tenei te manawanui. Na roto i te whakapataritari āhuatanga ngā therapy radiation (mo te mate pukupuku), te marama hihi katinga (ki kōiwi, mate inflammatory o nga sinuses, ruma maimoatanga antibacterial), mara autō (MRI, CT, therapy tinana) wā i roto i te ruma hyperbaric (i roto i te poliomyelitis, teitei mate).
Ārai ko Therapy
Kaimahi e mahi ana i roto i te rentgenkabinetom, orderlies me nēhi, mātanga i tua, maunga, iwi ki te taimaha te taikaha e hiahia ana koe ki te kai kai kei roto antioxidants tūturu: ika, putirā ranei te hinu oriwa, otaota, hua, tea matomato. I tua atu ki te huri i te kai, e taea te whakamahi taero e here ki etahi rōpū ngā Radicals free ki ngā konganuku o valency tāupe ranei. Ko te kupu e tu noa o ngā rāpoi ngota hāora kaha ratou, te ārai ratou i here ki amplifiers peroxidation lipid.
tātaringa
I te wā o te whanaketanga o te rangahau taiwhanga o nāianei e taea ki te kite waikuratei i te hanganga o fluids koiora o te tinana tangata tatou. Ki te mahi i tenei, te kawe i roto i fluorescence Microscopy. Mämä noa iho, ki te tautuhi i te peroxidation lipid. Me kore whakamārama te uara o tenei whakamātautau tātaritanga. Oia mau, i roto i te mate nui nui hāngai he mahi nui o te peroxidation lipid. Haurapa o tenei kāwanatanga whakatau maimoatanga.
Mai i te tirohanga o te whaiaroaro noa o te peroxidation lipid he tika mo te hanganga o hormones pūtaiaki, kaitakawaenga inflammatory, cytokines me thromboxanes. Otira ka nui te maha o ngā hua utu tauhohenga raraunga matū nga tīkina uara me kino hauwai organelles pūtau, DNA me te whakapōrearea i te kōtuitui o te pūmua, i roto i te pānga tomo pūnaha antioxidant e whakaiti te nui o Radicals hāora noa me katote o te konganuku ki valency tāupe. I tua atu, e faarahi te reira i te ariā o catalase me peroxidase mō tikanga o peroxides te taikaha me ngā hua o to ratou pākia atu.