Inhibitors ACE - drugs whai hua o te mafatu hou

Inhibitors ACE angiotensin tahuri take i huaina vasodilators puai whakamahia i roto i te mafatu mo te maimoatanga o te takawhita ranei. roa te mahi o tenei rōpū o taero e ārai adrenal taiaki angiotensin II - pressor tauwehe matua e pa ana i te uara pēhanga toto. ACE inhibitors ārai te rärangi o bradykinin, ano e pā te huru o oko, a konei i runga i te wahi tiketike o te pēhanga toto. tauturu i ēnei taero ki te whakapiki ake i te taumata toto o prostaglandins vasodilator whakaiti tohu o te kore ngakau ma'i, e maha kitea i roto i te tūroro ki te takawhita faufaa. I te wa ano, ACE inhibitors, pērā i ētahi atu raau taero e te raro pēhanga toto i kahore pānga i runga i te kūhuka me lipid ka pākia, whakaiti whatukuhu pūmua mimi.

E whakamahia ACE inhibitors mō neke atu i te 40 tau. Ko te tuatahi o tenei rōpū o raau taero i roto i te tau 1975 i synthesized captopril, whakamahia tenei ra. He tau torutoru i muri i whiwhi ia enalapril me lisinopril. i whakakapi ratou e atu inhibitors ACE hou te whakatupuranga hou.

I roto i te mafatu hou e whakamahia inhibitors ACE rite te raau taero matua mo te maimoatanga o hypertensive mate, manawa toto pūroto, kore ngakau ma'i.

ACE inhibitors whakarōpū

He maha ngā whakarōpū o inhibitors ACE, e hāngai ana ki te tango ara o taero i te tinana, i runga i te rōpū matū i roto i te rāpoi ngota pāhekoheko ki pokapū ACE o kaupae mahi rānei. Ko te whakarōpū tino noa o te mahi pharmacological.

E ai ki te mahi pharmacological o angiotensin tahuri inhibitors e wehea āhuatanga katoa ki ngā rōpū e toru.

Ko te rōpū tuatahi he captopril autahu'araa ranei, e tika inhibits, i.e. inhibits te angiotensin faafariuraa ahau mahi o te ira tangata i roto i te wāhanga o muri - angiotensin II. Ki te mau tonu captopril kapoten pēhanga toto noa tangohia e toru ki te wha nga wa he ra ranei.

Ki te rōpū tuarua no enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril me ētahi atu taero e kua tahuri i roto i te tinana ki pūhui kaha e whai he pānga vasodilatory. He nui ki te tango kotahi anake te ra enei taero.

I te pae hopea, ngā tuatoru te rōpū o lisinopril Zestril, prinivil, prestarium perindopril ranei. He ACE inhibitors tūtohutia te toru o te rōpū ki te tango kotahi, e rua i roto i te ra.

pānga te taha o inhibitors ACE

A, no te riro koe kia mōhio o te whanaketanga ka taea o ngā pānga kōaro tenei rōpū o taero. I roto i ētahi wā, tango inhibitors ACE kia puta mare maroke, nui haere taumata pāhare pāporo i roto i te toto, whanoke, ponana kiri mate pāwera, angioedema. E tino whakakorea ēnei pōauautanga i muri i te withdrawal tarukino. puta mare maroke i roto i te toru-te rima o te maimoatanga te ra. Ko tōna ahua he tika ki te haaputuputuraa i roto i te pūkahukahu o bradykinin. Mare riro rawa i muri i korenga atu o inhibitors. kia whakaiti ētahi tūroro hiahia me te tirohanga reka ohorere.

Ko tētahi o nga contraindications nui ki te whakamahi o inhibitors ACE he më constriction iatuku tākihi. I roto i tenei take, nui haere te pēhanga toto e, i tana whakaarahanga i te taumata o te renin i roto i te toto ki ai enei taero i kahore pānga.

kia tiaki motuhake kia hoatu inhibitors ACE i ma'i ate me te tākihi mate ki te whanaketanga o ngā tohu o te iti hoki ate, me te tākihi.