Mate o Alzheimer: take me te maimoatanga, te ngako, te tohu tuatahi, te whanaketanga, whakaahua o te mate o Alzheimer

mate o Alzheimer - he mate e arata'i ki te mate o ngā pūtau roro. Tahi e kino disorders hinengaro, me te mahi. Ko tētahi o te pokapū mate io, ko tonu nga tikanga o nei kihai i matau tino.

tikanga o te tātaritanga

Ko te taputapu matua mō te rangahau i runga i te whanaketanga o te tupu ko neuroimaging. Hoki tenei whakaaro, CT, MRI, PET roro. tirohia te tākuta te tohu o te whakangaromanga o hea takitahi, me te aro mātai ana te take ka taea, me te mate rere.

Mā te Tirohia te tukanga e āhei ki tatou mau mahi roro me te tohu o te waimaero o hononga neural. Laboratory tātari whakau mate o Alzheimer, whakaatu he hekenga whakaari i roto i te α-β-42 me te hua tukutahi o tau pūmua.

Take o mate o Alzheimer

E kore kua Ko te ngako o te mate o Alzheimer ano whakakitea ki te pūtaiao i roto i. I teie mahana, i reira e he torutoru ariā e pā ana ki te take o te putanga me te whanaketanga o te mate, engari he ano tetahi o ratou ki te riro āhukahuka ao. Ko te wahi nui i roto i te rangahau e whakaarohia e te take ira.

I roto i te tahi atu mea, te wehewehe i 3 ngā rōpū o te mōrearea mate:

• nekorrigiruemye;
• wāhanga correctable;
• correctable.

te mate o Alzheimer, ai me te maimoatanga o tenei mate - he rawa matatini, me te kāore mo te kau katoa o enei pātai i ngā āhuatanga nekorrigiruemyh.

Ko te take iranga i roto i te whanaketanga

Ko ake ki te 10% o te wā korerotia katoa māuiuitanga tuku. Ko te whanaketanga o te mate o Alzheimer i runga i te tikanga ira tīmata i mua 65 tau o te tau. Gene tuku i roto i te ahua tino autosomal: ara ki te kahore he tuarua te matua he kawe, tuku ki a ratou whakakapi pathological ira hauora. tamaiti tuku tūponotanga o te tikanga puta i roto i te hawhe o nga take.

Ahakoa te take iranga kï, he whakaaro e whai wāhi i te whanaketanga o te mate ki ngā momo rerekē o pūira pūtaiao. Nuinga tata, i roto i te akoranga o te koha ira rangahau i kitea e te pūira 14, i roto i 70% o ngā take arata'i ki te whanaketanga o te mate.

Maumaui o pūira 21 e meinga Down syndrome, i roto i te 5% o ngā take arahi ki tīmatanga wawe o te mate o Alzheimer. Ko te māuiuitanga tino onge - koha ira i runga i te pūira 1 - He tūponotanga iti o "whānau" o mate.

āhuatanga mōrearea tiketike

take Nekorrigiruemye He abnormalities kikokiko whaiaroaro ranei congenital riro ranei, e kore e taea te hanga ko kua puta ke ranei. Ēnei āhuatanga ngā:

• koroheketanga (i runga i 80 tau);
• he wahine;
• whētuki cranial;
• whārua nui me te ahotea;
• te kore o "whakangungu" mo te hinengaro.

Tetahi wahi āhuatanga modifiable kėia he rōpū o mate e meinga hē hāora whakapeka ma'i ranei i roto i te pūtau uho kaka:

• takawhita;
• atherosclerosis o oko o te kaki, te pane, te roro;
• pākia lipid;
• mate huka;
• mate ngakau.

Whakakorenga o te mate te whakaiti i te tūponotanga o te mate o Alzheimer.
Hoki correctable - Kei te tino whakakorea - kia ngā āhuatanga:

• heke mahi tinana;
• kore o te whanaketanga hinengaro, iti;
• kore ki te ū ki te mau parau tumu o te āhua noho hauora.

e kore e 100% te kī mo te whanaketanga o te mate pathologies, engari maha mua reira, ārahi ki te mutunga e pā ana ki te āhuatanga mōrearea taea, me te ārai.

atamira whanaketanga

Kua kitea Scientists e mate o Alzheimer (tohu tuatahi) puta i roto i 15-20 tau, ki nui pikitia haumanu, i nui fakafaingata'a'ia'i te ārai o te mate. I teie mahana, Kei te hoatu reira 3 pathological tukanga takahanga:

1. Mua-haumanu - māuiuitanga i aruaruraa, e kitea CNS disorders.
2. Wā maumaui iti - kia kite tūroro he vaivai o ngā kaha hinengaro, me te waimaerotanga mahara.
3. Ko te tohu tuatahi o te tupu - te porowhita roto tīmata ki te kite i te he te tahi mea. Nuinga o ngā wā, ka taea e koe te whakaū i te aroaro o te mate hauora.

Ia o nga wāhanga he ona ake āhuatanga, me te huarahi ki te whakarato o te tiaki hauora.

Ko te whanaketanga o te mate i te kuao tau

whakawhanake mate wawe a Alzheimer te aroaro o te tau o te 65 tau, he uaua ki te tātari i roto i te wa e tika ana ki te pikitia haumanu nonspecific. puta te tohu tuatahi i roto i te puka o te warewaretanga, aravihi ki te whakamahere me te mahi nga mea i nga ngāwari i mua. Te manawanui hohoro riro ngenge o te mahi hinengaro: ki te pupuri i te kōrero i roto i te mahara kei te hoko piki uaua.

mate o Alzheimer: take me te maimoatanga i te wā wawe

whakawhanake te wāhanga tuatahi i roto i 7 nga tau. huringa tuatahi i roto i te huru o te manawanui tango wahi i raro i te mana o ngā āhuatanga rerekē. I roto i te take o te take pumau o nga ope katoa ka tono ki tona whakakorenga. Ka rite ki te tikanga, maimoatanga rohe homai hua pai.

kia amuamu tūroro o Alzheimer o:

• raruraru pūmahara;
• ahua te warewaretanga;
• mate o te kaha ki te whakaaro;
• disorders psycho-aronganui.

Mahalo i kua Alzheimer o hei whanaunga kitea. E kore hāngai tonu tohu tohumate tuatahi pōrearea roro, engari tokomaha rapu tonu tauturu a te taote, me te wa ki te ako e pā ana ki te tātaritanga.

disorders mahara i te āhua wā-poto me te wā roa-, a kahore e taea ki te kite ino tonu te manawanui. Ko te warewaretanga tino whakarihariha: maha iwi ki maui o Alzheimer i hau hiko ranei, e tika ana ki te mahinga o te huru tino. Mahalo puta te mate o te faaiteraa o te mahara kore-ahua i roto i te puka o te warewaretanga o ngā i roto i te mua. haamana'oraa faaho'iraa mai Motunga puta i rōpū. hohoro disorders mahara i mua: i muri marama 6 anake, riro nga tohu atu korerotia, me te mōrearea mō te ora o te manawanui.

Te rironga o te kaha ki te whakaaro tei runga i te taumata o te maramarama ki te whanaketanga o te mate. I te tahi taime te tohumate āhuatanga ko te huringa koi o ngā ngākau nuitanga: matakitaki ana TV hei utu o pānui tuhinga uaua, me te tahi atu mau taime. ngā mōhiohio tukanga fakahohaasi me te tirohanga o te taiao tukatuka ambient, ngaro ai te te manawanui i roto i te wāhi me te wā.

disorders Mental rite kaha peia a Alzheimer

Ka taea e ngā raruraru hinengaro, me te aronganui nui meinga te mate o Alzheimer. Ko te take o taua tohu, me te takoto maimoatanga i roto i mate roro, me te tūkino āriponga o ponana karere. arata'i kōtuitanga acetylcholine iti ki te hanganga o whakatū papa amyloid. korekore wā-roa pēhia te mahi o te pūnaha io, a ki te whakamārama o te mahi ngoikore o te whakawhanake tupu.

Maumaui o te kāwanatanga aronganui pāngia e te mate o Alzheimer. Ko te tuatahi tohu o te mate hinengaro faaite i roto i te whakaoho kaha, mahi mahi pakeke, me te tikanga, amuamu o moe te pehi, me te fitful. I te tahi taime, to ratou mau aroraa o āhotea whakapeka, āhuatanga e te wehi aitua o fakatangá, wā. Whakapataritari i te huringa kāwanatanga o tetahi āhua: i te whakatikatika o te taonga i mua i neke ki tetahi atu whare. haere tahi kauneke o te mate e te huringa o te manukanuka whānui ki te tau'a. maimoatanga Human ki nui disorders hinengaro tā i roto i ngā te whakamahi o pōuritanga me taero psychotropic.

Mate o Alzheimer: Okú, maimoatanga o te atamira 2

mahara whara Serious, āhuatanga anake hoki tenei mate hei kitea me te ake kino i roto i te wāhanga tuarua o te whanaketanga o te māuiuitanga. E kore te manawanui e taea mahara etahi ngā, ara ka te āwhina herekore me ētahi atu ki whanaunga. Tuatahi o te katoa, wareware tūroro te raruraru tata, i te mua tawhiti tonu i roto i te mahara.

Maumaui o aauraa wā-poto arahi ki te takotoranga hē i roto i te wa. e kore e taea e ki tika whakaturia te wā wa o tetahi ki tetahi hui ranei tupu. I raro i te whanaketanga mate āhua kitea te whakakī Memories mahara oranga e kia whai i te ihirangi rerehua.

arata'i kauneke ki mate katoa o te matauranga o te tueke, i roto i ngā hua i roto i te pakeke me te he i te hanganga matatini. Puritia anake aua pūkenga e kua werohia i roto i te kōhungahunga me te tonu toutou i te akoranga o te ora. Hei tauira, te matauranga o te arero whaea, kōrero ara ki te iwi, me te whaiaro ratonga-.

He āhuatanga motuhake o te tupu i roto i te wā 2 - te tiaki o te mahara aronganui me te ngaro o te tūturu. E mea pinepine e kore tūroro e mahara mehemea whai tamariki, he mokopuna ranei ratou, engari whakapā ki a ratou ai oaoa, te oaoa.

mate o te maramarama

Ko te take tino i roto i te atamira 2 nd - maumaui o ngā kaha hinengaro, e te mutunga arata'i ki mate o motuhake. Whakawhanake tupu e taea te wehea ki ngawari, āhua, me te kino.

faaite faaiteraa o te tupu ngawari te i roto i te mate o te kaha ki te whakahaere i te moni: e kore e taea ki te whakaki i roto i te pūkete, ki te tātai i te nui ki te utu. Ina e ngaro te kupu riro, riro te reira kau. Tikanga, tamata tūroro i tenei wā ki te karo takoto. Ohorere pai pūkenga nekeneke o ringa, hua i roto i te reta pokanoa noa. He hapa wetereo matotoru, kihai nei i i te tīariari i mua.

tupu ngawari āhuatanga e te mate o te pānui me te tuhituhi pūkenga, maha riro hé kupu o te manawanui e tika ana ki te wareware o kupu ki te whakakapinga muri i te-tangi rite. Te tangata riro atu rawakore: taea takitahi ki te taka mo te rangi, kitea ratou ara te kāinga, wareware ki te tahuri atu te umu wai ranei. I runga i te wāhanga 2 nd o te mate o Alzheimer ki manawanui tupu āhua kua hiahiatia āwhina tamau me te aroaro o whanaunga.

tupu nui

āhuatanga te atamira whakamutunga o te mate o Alzheimer e te fakafalala oti i runga i ētahi atu. e kore e taea ki te hanga o ratou ake kai, haere ki te wharepaku, ki te kawe i roto i ngā tukanga mā te manawanui. riro incoherent me hano tatau, ohorere kiwi e Speech, hanga reira uaua ki te neke takitahi.

Āta wawahi iho, me te horomia pūpū. puta te mate e tika ana ki te rohirohi roa o sepsis mate nui ranei.

Tupu i roto i te mate o Parkinson

mate o Parkinson me Alzheimer o mo te tangata toharite he pikitia haumanu rite, taea anake te tātaritanga tika mātanga. He āhuatanga motuhake te tupu hua. āhuatanga mate o Alzheimer e te ofatiraa nui o te mahara, me te maramarama. kitea parkinsonism anake tērā o korero, me te whakaaro kei te. He āhuatanga noa o mate neurodegenerative ko te ino o āhua hinengaro, me te aronganui. Tūroro hoki te wa roa i roto i te āhua o te whārua, me te āhotea whakapeka.

E whakaatu ana te pikitia e te mate o Alzheimer (i runga ake), me a Parkinson (whakaahua i raro nei) pā te roro i roto i nekehanga rerekē. whakawhanake te mate tuatahi i roto i te taupa pae tino, me nga whakatū papa amyloid hippocampus e puta ana arahi ki te mate o hononga karere (tīmata te roro ki te "maroke i roto i").

mate a Parkinson tuwhena pānga te pūnaha musculoskeletal: piko te tuarā te ake, kei te whiwhi raro me raro i te manawanui. Āwangawanga e pā ana ki te faaati tonu, hei diskoordinirovannymi nekehanga.

Maimoatanga o te atamira wawe

arotakehia matou i roto i ngā whānui, e ko te mate o Alzheimer. Ai a te wā e kore e tino matau maimoatanga o te mate na roto i te pūtaiao. Doctors e mahi tonu rangahau ki te kitea he tarukino whai hua, engari e kore te mea te tarukino ano he huinga ake ahurei, taea ki te hinga i te mate.

Maimoatanga mō te matatini tënei o:

• maimoatanga o disorders hinengaro;
• whakapakari whānui o te tinana;
• te whakatū pākia i roto i te roro;
• te whakapakari i nga oko toto;
• maimoatanga whānui o Alzheimer o.

wā nui ki te tīmata tango i te rongoā, me te whakarite hanganga ture tino ki tūtohutanga rata katoa. Kia mataara he tika i roto i te akiaki i te ahunga whakamua o te mate.

Hoki te maimoatanga o ngawari ki te whakaōrite whakamahi tupu taua taka:

• "Piribedil" - whakapiki i te tuku o ponana karere i roto i te neurotransmission dopaminergic me noradrenalinergicheskih CNS. Te whakapai ake mahara me ngā āheinga hinengaro.
• "Pentoxifylline," "Vinpocetine" - whakapiki i tohanga toto, te ārai i te hanganga o te thrombi i roto i nga oko kaka.
• Ginkgo biloba wāhanga - whakaongaonga te hanga o neurotransmitters, tiaki pūtau roro i tāoke, whakapiki i te tohanga toto.
• "Cinnarizine," "Nimodipine" - te whakawhānui i te oko toto roro, te tiaki i ngā pūtau i te pānga kino o te konupūmā te taikaha.
• Pyrrolidone me ona pärönaki - whakapiki i te supply hāora o te roro whai wāhi ki te māori o te kōtuitanga pūmua i roto i ngā pūtau roro.
• "Aktovegin" "te aau" - whai wāhi ki te faaho'iraa mai o te mekameka mōhiohio, ki te whakaongaonga i ngā tukanga whakawhiti intracellular.

therapy taiki

whakaae Scientists e whai wāhi te whanaketanga o te mate o Alzheimer ki te whakaiti i roto i te acetylcholine kōtuitanga. Tāne i waenganui i hanga, me te acetylcholine neurotransmitter acetylcholine, e ai te inhibition o ngā mahi neuronal. riro nga pūtau mingimingi, riringi wāhi synapse te, a ka mate neurons. Opening i roto i 100% o ngā take o ne fakapapau◊i te mate o Alzheimer. Whakaahua o te roro tangata hauora, me te mate tukua ki a matou e kite i te māuiuitanga o te ara tangata noa.

Iti whakahokia kōtuitanga acetylcholine taea taunekeneke i waenganui i neurons me pōturi iho nga tukanga o te hanganga o whakatū papa amyloid. Kua whakaaturia tamataraa haumanu te miramira o inhibitors cholinesterase. I roto i te tūroro ki te hekenga i o tupu, whakahokia mahara te, hoki mai nga pūkenga mahi-whaiaro, me te te takotoranga i roto i te wāhi me te wā.

I teie mahana e mōhiotia whānuitia 3 Drugs e tautāwhi i cholinesterase:

• "Aritsept" ( "donepezil" "Aricept") - he pānga pokapū, tono i runga i 5.10 mg ia ra.
• 'Reminyl' (galantamine hydrobromide) - he pānga whānui, ngā kore-paitini, arotahi pai. Hoatu 8-12 mg ia ra.
• "Exelon" ( "rivastigmine") - he pānga pokapū, atu whai hua atu i te tahi atu raau taero i roto i te puka tere ahu whakamua o te mate o Alzheimer. Wātea i roto i te puka o papa, raima, moata. Tīmata horopeta - 3 mg ia ra.

Ko te whakamahi o cholinesterase inhibitors rongoā hoatu āhua i te taua hua, engari tauhohe ia manawanui rerekē ki te taiki therapy. Ki te kore tetahi o nga taero i pai, whakakapi te tākuta ona te orotahi. Whakawa he taea te putanga o te maimoatanga i muri anake i te akoranga e toru-marama i te inenga mōrahi.

Ko te contraindications matua he mate o te wahi gastrointestinal, ngakau, me te mimi. Kei te kore hoki tūtohutia Taupānga o huangō arahau, me te haurangi.

Maimoatanga o te tupu nui

huringa tina heke i roto i te roro ai te mate o Alzheimer. Ko te take o te mate - he take nei ia tonu kairangahau. I te wā whakamutunga o te mate, ko te taea ki te whakamahi i tetahi anake raau whakaaetia e te ao o te rongoā - "Memantine". e kore te tukanga degenerative i roto i neurons whakahaeretia e tetahi cholinesterase anake, riro te āhuatanga uaua ake. astrocytes roro, timata ki te whakaputa i te tāoke - glutamate, e whakamate neurons me astrocytes ratou.

"Memantine" regulates te utu o te glutamate, e ārai te āhua o te haurangi o te roro. Kei te mahi tokomaha tohunga te whakamahi o "Memantine" tahi ki inhibitors cholinesterase, e maha homai hua pai.

Kei te mohio a pai te raau i te tinana, te mea i te torutoru contraindications (haurangi me te waimaero mahi tākihi). whenua US ko EU tono "Memantine" mo te maimoatanga o te mate o Alzheimer mō te 10 tau.

therapy symptomatic

hāngai Treatment te i runga i te whakamahi o inhibitors serotonin reuptake whiriwhiri ( "fluoxetine", "citalopram") me te norepinephrine. I tua atu ki te whai pānga pai i runga i te raau taero konä i te āwhina te whakakore tohu o tupu ngawari. Mā te pōuritanga angamaheni taea arahi ki te whanaketanga o te mate o Alzheimer, na i roto i te korekore nui whakahau pōuritanga tricyclic.

A, no te whakamahia neuroleptics disorders psychotic. Heoi, kia whanau ai i roto i te ngakau e whakarei ratou te faaiteraa o te tupu. Whakamahia ratou anake i roto i te wā tino, te mau taote whakahau taero anake pānga ngawari.